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CATH Superfamily 3.60.15.10

Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28590: N-acyl homoserine lactonase AttM

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Quorum-quenching N-acyl-homoserine lactonase. [EC: 3.1.1.81]
An N-acyl-L-homoserine lactone + H(2)O = an N-acyl-L-homoserine.
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria.
  • N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
 8 A0A083ZME2 A0A0Q7PDE6 A0A1H8W1E8 A8IQD2 Q1M813 Q7D3U0 Q8VPD5 W8FHP5
Hydroxyacylglutathione hydrolase. [EC: 3.1.2.6]
S-(2-hydroxyacyl)glutathione + H(2)O = glutathione + a 2-hydroxy carboxylate.
  • Also hydrolyzes S-acetoacetylglutathione, more slowly.
  • Formerly EC 3.1.2.8.
 3 A0A083ZME2 A0A0Q7PDE6 Q7D3U0