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CATH Superfamily 3.60.10.10

Endonuclease/exonuclease/phosphatase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Endonuclease/exonuclease/phosphatase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13487: Glucose-repressible alcohol dehydrogenase transcri...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Poly(A)-specific ribonuclease. [EC: 3.1.13.4]
Exonucleolytic cleavage of poly(A) to 5'-AMP.
  • Cleaves poly(A) in either the single- or double-stranded form.
 174 A0A096N5M3 A0A096N5M3 A0A0B0E016 A0A0B0E016 A0A0B2QM42 A0A0B2QM42 A0A0B2R7Q5 A0A0B2R7Q5 A0A0B2SH22 A0A0B2SH22
(164 more...)
DNA-(apurinic or apyrimidinic site) lyase. [EC: 4.2.99.18]
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
 2 A0A1E4SVP7 A0A1E4SVP7
Adenylate kinase. [EC: 2.7.4.3]
ATP + AMP = 2 ADP.
  • Inorganic triphosphate can also act as donor.
 2 A0A1B0GMG3 A0A1B0GMG3