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CATH Superfamily 3.60.10.10

Endonuclease/exonuclease/phosphatase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Endonuclease/exonuclease/phosphatase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13471: DNA-(apurinic or apyrimidinic site) lyase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Exodeoxyribonuclease III. [EC: 3.1.11.2]
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.
  • Preference for double-stranded DNA.
  • Has endonucleolytic activity near apurinic sites on DNA.
  • Similar enzyme: Haemophilus influenzae exonuclease.
  • Formerly EC 3.1.4.27.
 502 A0A017H7Q6 A0A059N1D6 A0A069AEU0 A0A069SNU7 A0A078R4C0 A0A080UKW1 A0A090I175 A0A090YLX0 A0A0A0U112 A0A0A7G116
(492 more...)
DNA-(apurinic or apyrimidinic site) lyase. [EC: 4.2.99.18]
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
 326 A0A022PZ48 A0A023F9C7 A0A023GKM3 A0A026VTL7 A0A034V256 A0A034V4B9 A0A059A3C6 A0A059Q2Q5 A0A060XLE4 A0A061EWR9
(316 more...)