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CATH Superfamily 3.40.830.10

LigB-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
LigB-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1458: 4,5-DOPA dioxygenase extradiol 1

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-carboxyethylcatechol 2,3-dioxygenase. [EC: 1.13.11.16]
(1) 3-(2,3-dihydroxyphenyl)propanoate + O(2) = (2Z,4E)-2-hydroxy-6- oxonona-2,4-diene-1,9-dioate. (2) (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O(2) = (2Z,4E,7E)-2- hydroxy-6-oxonona-2,4,7-triene-1,9-dioate.
  • This enzyme catalyzes a step in the pathway of phenylpropanoid compounds degradation.
 826 A0A009EQ84 A0A009JBI2 A0A013TM74 A0A014MAY6 A0A022L1Q8 A0A022PQF1 A0A023C948 A0A023V8H2 A0A023YSS5 A0A024K4W1
(816 more...)
Protocatechuate 4,5-dioxygenase. [EC: 1.13.11.8]
Protocatechuate + O(2) = 4-carboxy-2-hydroxymuconate semialdehyde.
  • Formerly EC 1.13.1.8.
 255 A0A014NK51 A0A024YW29 A0A031HYG0 A0A031I4U7 A0A038H0A4 A0A060V8J8 A0A062VL19 A0A062VP45 A0A069I3D4 A0A069P8H9
(245 more...)
Stizolobate synthase. [EC: 1.13.11.29]
L-dopa + O(2) = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde.
  • The intermediate product undergoes ring closure and oxidation, with NAD(P)(+) as acceptor, to stizolobic acid.
 30 A0A064T9W3 A0A077ZIN1 A0A090H2D5 A0A0A0FIX6 A0A0E0VB11 A0A0E1M1E1 A0A0H3MUL4 A0A0H3XC32 A0A0M7P6I4 A0A0P0AJH8
(20 more...)
Gallate dioxygenase. [EC: 1.13.11.57]
Gallate + O(2) = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate.
  • The enzyme is a ring-cleavage dioxygenase that acts specifically on gallate to produce the keto-tautomer of 4-oxalomesaconate.
 26 A0A060V8J8 A0A087FMF2 A0A0C7F3L9 A0A0H2MKF0 A0A0H3H4Q3 A0A0J2GME9 A0A0J4LY58 A0A0M1TGP2 A0A0M2QRN6 A0A0P0RFF3
(16 more...)
Catechol 2,3-dioxygenase. [EC: 1.13.11.2]
Catechol + O(2) = 2-hydroxymuconate-6-semialdehyde.
  • The enzyme initiates the meta-cleavage pathway of catechol degradation.
  • Formerly EC 1.13.1.2.
 4 A0A0E2WU78 A0A0H3A2B4 C6RT92 X8B692
2-aminophenol 1,6-dioxygenase. [EC: 1.13.11.74]
2-aminophenol + O(2) = 2-aminomuconate 6-semialdehyde.
  • The enzyme, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent).
  • The enzyme also has some activity with 2-amino-5-methylphenol and 2-amino-4-methylphenol.
  • The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.76.
  • Formerly EC 1.13.11.n1.
 4 A0A0H4W7R3 O33477 Q2PQU1 Q6J1Z6
3,4-dihydroxyphenylacetate 2,3-dioxygenase. [EC: 1.13.11.15]
3,4-dihydroxyphenylacetate + O(2) = 2-hydroxy-5-carboxymethylmuconate semialdehyde.
    		 3 A0A024HKA1 Q13VT6 Q706S5
    2-amino-5-chlorophenol 1,6-dioxygenase. [EC: 1.13.11.76]
    2-amino-5-chlorophenol + O(2) = 2-amino-5-chloromuconate 6-semialdehyde.
    • The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent).
    • The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.3.1.74.
    		 2 Q2PQU1 Q6J1Z6
    Protocatechuate 3,4-dioxygenase. [EC: 1.13.11.3]
    3,4-dihydroxybenzoate + O(2) = 3-carboxy-cis,cis-muconate.
    • The enzyme, which participates in the degradation of aromatic compounds, catalyzes the intradiol addition of both oxygen atoms from molecular oxygen, resulting in ortho-cleavage of the aromatic ring.
    • The type of cleavage leads to mineralization via the intermediate 3-oxoadipate.
    • Formerly EC 1.13.1.3 and EC 1.99.2.3.
    		 1 A0A069PLX6
    3-(3-hydroxy-phenyl)propanoic acid hydroxylase. [EC: 1.14.13.127]
    (1) 3-(3-hydroxyphenyl)propanoate + NADH + O(2) = 3-(2,3- dihydroxyphenyl)propanoate + H(2)O + NAD(+). (2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O(2) = (2E)-3-(2,3- dihydroxyphenyl)prop-2-enoate + H(2)O + NAD(+).
    • This enzyme participates in a meta-cleavage pathway employed by the bacterium Escherichia coli for the degradation of various phenylpropanoid compounds.
    • Formerly EC 1.14.13.n3.
    		 1 X8CPM3