The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Alkaline Phosphatase, subunit A

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19113: Alkaline phosphatase, tissue-nonspecific isozyme

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Alkaline phosphatase. [EC:]
A phosphate monoester + H(2)O = an alcohol + phosphate.
  • Active at a high pH optimum.
  • Wide specificity.
  • Also catalyzes transphosphorylations.
  • Some enzymes hydrolyze diphosphate (cf. EC
2140 A0A009KHZ6 A0A009LIU8 A0A010RMF6 A0A015IVR8 A0A015KNJ7 A0A017IKX5 A0A017SN90 A0A022IVJ3 A0A022VY38 A0A022W972
(2130 more...)
4-nitrophenylphosphatase. [EC:]
4-nitrophenyl phosphate + H(2)O = 4-nitrophenol + phosphate.
  • A number of other substances, including phenyl phosphate, 4-nitrophenyl sulfate, acetyl phosphate and glycerol phosphate, are not substrates.
(41 more...)
Farnesyl diphosphatase. [EC:]
(2E,6E)-farnesyl diphosphate + H(2)O = (2E,6E)-farnesol + diphosphate.
  • The enzyme is involved in the biosynthesis of acyclic sesquiterpenoids.
4 C8Z639 N1P5R2 P11491 S5YEJ1
Streptomycin-6-phosphatase. [EC:]
Streptomycin 6-phosphate + H(2)O = streptomycin + phosphate.
  • Also acts on dihydrostreptomycin 3'-alpha,6-bisphosphate and streptidine 6-phosphate.
4 B1W385 G0Q8I6 P09401 Q53IC4
Fructose-2,6-bisphosphate 6-phosphatase. [EC:]
Beta-D-fructose 2,6-bisphosphate + H(2)O = beta-D-fructofuranose 2-phosphate + phosphate.
  • Cf. EC
4 C8Z639 N1P5R2 P11491 S5YEJ1
Peptidoglycan glycosyltransferase. [EC:]
(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)- diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys- D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.
  • The enzyme also works when the lysine residue is replaced by meso- 2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-center, as it is in Gram- negative and some Gram-positive organisms.
  • The undecaprenol involved is ditrans,octacis-undecaprenol.
  • Involved in the synthesis of cell-wall peptidoglycan.
1 A0L144
Phosphoserine phosphatase. [EC:]
O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.
    1 A0A159WBW6