The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
DD-peptidase/beta-lactamase superfamily
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22220: Beta-lactam binding protein AmpH

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Muramoylpentapeptide carboxypeptidase. [EC: 3.4.17.8]
Cleavage of the bond UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-6- carboxy-L-lysyl-D-alanyl-|-D-alanine.
  • Does not cleave the C-terminal D-alanine from the product of the above reaction, UDP-N-acetyl-muramoyl-L-alanyl-gamma-D-glutamyl-6- carboxy-L-lysyl-D-alanine.
  • Competitively inhibited by penicillins and cephalosporins.
  • Belongs to peptidase family M15.
  • Formerly EC 3.4.12.6.
150 A0A026V595 A0A027TTT0 A0A028AGV1 A0A028DMA7 A0A029IAW6 A0A029J0Z4 A0A029LVZ0 A0A037Y958 A0A060V2J6 A0A069XMV9
(140 more...)
Beta-lactamase. [EC: 3.5.2.6]
A beta-lactam + H(2)O = a substituted beta-amino acid.
  • Zinc is only requires in class-B enzymes.
  • A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins.
  • Formerly EC 3.5.2.8.
150 A0A026V595 A0A027TTT0 A0A028AGV1 A0A028DMA7 A0A029IAW6 A0A029J0Z4 A0A029LVZ0 A0A037Y958 A0A060V2J6 A0A069XMV9
(140 more...)
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