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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63411: Histidinol-phosphate aminotransferase (Imidazoleac...

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histidinol-phosphate transaminase. [EC: 2.6.1.9]
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
    		 1715 A0A011VCB9 A0A014QCP0 A0A016XL01 A0A021XD91 A0A022FQP4 A0A031GPZ1 A0A031HYI8 A0A037Z2M1 A0A038GRD7 A0A058YB11
    (1705 more...)
    Threonine-phosphate decarboxylase. [EC: 4.1.1.81]
    L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO(2).
    • Unable to decarboxylate the D-isomer of threonine O-3-phosphate.
    • The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of EC 6.3.1.10, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway.
    		 22 A0A097ANX9 A0A097B4H8 A0A0B3B9Z9 A0A0B8QXY2 A0A0D0EQ79 A0A0D8IGH2 A0A0E1R4X1 A0A0F5Z2E7 A0A0H3IPF3 A0A0H4RDL0
    (12 more...)
    Histidinol dehydrogenase. [EC: 1.1.1.23]
    L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH.
    • Also oxidizes L-histidinal.
    • The Neurospora enzyme also catalyzes the reactions of EC 3.5.4.19 and EC 3.6.1.31.
    		 4 A0A0B6WW68 C1A4M1 E6PX81 E7S0X8
    Aspartate transaminase. [EC: 2.6.1.1]
    L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
    • Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.
    • This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
    		 3 A0A0W8F3W9 A0A0W8F7Z1 A0A0W8FFV9
    Tyrosine transaminase. [EC: 2.6.1.5]
    L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
    • L-phenylalanine can act instead of L-tyrosine.
    • The mitochondrial enzyme may be identical with EC 2.6.1.1.
    • The three isoenzymic forms are interconverted by EC 3.4.22.32 and EC 3.4.22.33.
    • The enzyme can also catalyze the final step in the methionine-salvage pathway of Klebsiella pneumoniae.
    		 2 C9R5S9 X2JRZ9
    Aromatic-amino-acid transaminase. [EC: 2.6.1.57]
    An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
    • L-methionine can also act as donor, more slowly.
    • Oxaloacetate can act as acceptor.
    • Controlled proteolysis converts the enzyme to EC 2.6.1.1.
    		 2 A0A085GXJ9 A0A1B7KGW7
    Imidazoleglycerol-phosphate dehydratase. [EC: 4.2.1.19]
    D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2- oxopropyl phosphate + H(2)O.
      		 1 A0A0S7BMV7
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