The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63395: Alanine aminotransferase 2, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
1-aminocyclopropane-1-carboxylate synthase activity GO:0016847
Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+).
13 A1IIT7 (/ISS) A5BL65 (/ISS) O24544 (/ISS) O65028 (/ISS) O80334 (/ISS) Q00257 (/ISS) Q09PK3 (/ISS) Q43165 (/ISS) Q6TRG0 (/ISS) Q8S935 (/ISS)
(3 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 Q06402 (/IPI) Q37001 (/IPI) Q43309 (/IPI) Q96QU6 (/IPI) Q9M2Y8 (/IPI) Q9S9U6 (/IPI) Q9SAR0 (/IPI) Q9STR4 (/IPI) Q9T065 (/IPI)
1-aminocyclopropane-1-carboxylate synthase activity GO:0016847
Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+).
9 P37821 (/IDA) Q06402 (/IDA) Q37001 (/IDA) Q43309 (/IDA) Q9M2Y8 (/IDA) Q9S9U6 (/IDA) Q9SAR0 (/IDA) Q9STR4 (/IDA) Q9T065 (/IDA)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
5 F4I7I0 (/IDA) Q4GYI2 (/IDA) Q8TD30 (/IDA) Q9LR30 (/IDA) Q9S7E9 (/IDA)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
5 Q10334 (/ISS) Q28DB5 (/ISS) Q6GM82 (/ISS) Q6NYL5 (/ISS) Q8BGT5 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 Q43309 (/IPI) Q96QU6 (/IPI) Q9SAR0 (/IPI) Q9STR4 (/IPI) Q9T065 (/IPI)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
3 P25409 (/NAS) P37821 (/NAS) Q96QU6 (/NAS)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
2 P24298 (/EXP) Q8TD30 (/EXP)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
2 P52893 (/IMP) Q9LR30 (/IMP)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
2 Q8BGT5 (/ISO) Q8QZR5 (/ISO)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
2 P24298 (/NAS) P25409 (/NAS)
Alanine-glyoxylate transaminase activity GO:0008453
Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.
2 Q9LR30 (/IDA) Q9S7E9 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P37821 (/NAS) Q96QU6 (/NAS)
Glycine:2-oxoglutarate aminotransferase activity GO:0047958
Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
2 Q9LR30 (/IDA) Q9S7E9 (/IDA)
L-alanine:2-oxoglutarate aminotransferase activity GO:0004021
Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.
1 C8VKU5 (/RCA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 F4I7I0 (/IDA)
Transaminase activity GO:0008483
Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
1 P52892 (/ISS)
1-aminocyclopropane-1-carboxylate synthase activity GO:0016847
Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+).
1 Q37001 (/IMP)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 A9NIT9 (/RCA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 A2AIG8 (/ISO)
Glycine:2-oxoglutarate aminotransferase activity GO:0047958
Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
1 Q9LR30 (/IMP)
Glycine:2-oxoglutarate aminotransferase activity GO:0047958
Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.
1 Q9S7E9 (/ISS)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-alanine metabolic process GO:0042851
The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
5 Q10334 (/ISS) Q28DB5 (/ISS) Q6GM82 (/ISS) Q6NYL5 (/ISS) Q8BGT5 (/ISS)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
4 Q28DB5 (/ISS) Q6GM82 (/ISS) Q6NYL5 (/ISS) Q8BGT5 (/ISS)
Ethylene biosynthetic process GO:0009693
The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
4 Q06402 (/TAS) Q9SAR0 (/TAS) Q9STR4 (/TAS) Q9T065 (/TAS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
3 F4I7I0 (/IEP) Q9LDV4 (/IEP) Q9LR30 (/IEP)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
3 Q43309 (/IEP) Q9M2Y8 (/IEP) Q9SAR0 (/IEP)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
2 P24298 (/TAS) Q8TD30 (/TAS)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
2 A9NIT9 (/IEP) Q9SAR0 (/IEP)
Ethylene biosynthetic process GO:0009693
The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
2 Q37001 (/IMP) Q9M2Y8 (/IMP)
Chronological cell aging GO:0001300
The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
1 P52893 (/IMP)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
1 Q9SAR0 (/IEP)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
1 Q37001 (/IMP)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
1 Q8TD30 (/IDA)
2-oxoglutarate metabolic process GO:0006103
The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism.
1 Q8BGT5 (/ISO)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
1 Q9M2Y8 (/IDA)
Alanine biosynthetic process GO:0006523
The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid.
1 P52893 (/IMP)
Alanine catabolic process GO:0006524
The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid.
1 Q4GYI2 (/IDA)
Alanine catabolic process GO:0006524
The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid.
1 P52893 (/IMP)
Aspartate metabolic process GO:0006531
The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid.
1 C8VKU5 (/RCA)
Proline metabolic process GO:0006560
The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
1 Q4GYI2 (/IMP)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q9SAR0 (/IEP)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 Q9SAR0 (/IEP)
Ethylene biosynthetic process GO:0009693
The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
1 P37821 (/IC)
Response to auxin GO:0009733
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.
1 Q9SAR0 (/IEP)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
1 Q37001 (/IMP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
1 A9NIT9 (/IEP)
Response to jasmonic acid GO:0009753
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.
1 Q9SAR0 (/IEP)
Photorespiration GO:0009853
A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria.
1 Q9LR30 (/TAS)
L-alanine catabolic process, by transamination GO:0019481
The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination.
1 F4I7I0 (/IMP)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 A0A1D8PJP4 (/IMP)
L-alanine metabolic process GO:0042851
The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
1 Q8TD30 (/IDA)
L-alanine metabolic process GO:0042851
The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.
1 Q8BGT5 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 F4I7I0 (/IEP)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
1 A9NIT9 (/IEP)
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
1 Q9SAR0 (/IEP)
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
1 Q37001 (/IMP)
L-glutamate biosynthetic process GO:0097054
The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid.
1 Q10334 (/IC)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 F4I7I0 (/IDA) P52893 (/IDA) Q7KV27 (/IDA) Q8BGT5 (/IDA) Q9VYD9 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q10334 (/IDA) Q4GYI2 (/IDA) Q7KV27 (/IDA) Q9VYD9 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 F4I7I0 (/IDA) Q9LR30 (/IDA) Q9S7E9 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
2 Q9LR30 (/IDA) Q9S7E9 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q8QZR5 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 C8VKU5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10334 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10334 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q10334 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q10334 (/ISS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8TD30 (/TAS)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 Q9LR30 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q9S7E9 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P24298 (/TAS)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 Q9S7E9 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9LR30 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
1 Q9LR30 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P24298 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q8QZR5 (/ISO)
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