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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63292: 8-amino-7-oxononanoate synthase BioF1

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
8-amino-7-oxononanoate synthase. [EC: 2.3.1.47]
Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].
  • The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis.
  • Pimeloyl-CoA can be used with lower efficiency.
 672 A0A023XXY2 A0A023XXY2 A0A031H6X5 A0A031H6X5 A0A045IZY8 A0A045IZY8 A0A060H292 A0A060H292 A0A060HGN5 A0A060HGN5
(662 more...)
6-carboxyhexanoate--CoA ligase. [EC: 6.2.1.14]
ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl- CoA.
    		 18 A0A0E1YIU7 A0A0E1YIU7 C4LK80 C4LK80 D1YF57 D1YF57 D4H9Y2 D4H9Y2 E4HHD8 E4HHD8
    (8 more...)
    Glycine C-acetyltransferase. [EC: 2.3.1.29]
    Acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate.
    • Acts in concert with EC 1.1.1.103 in the degradation of threonine to form glycine.
    • This threonine degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex.
    		 10 A0A0T9LI47 A0A0T9LI47 I0KZ69 I0KZ69 K0K9P6 K0K9P6 L7V5A4 L7V5A4 W5TD03 W5TD03
    Dethiobiotin synthase. [EC: 6.3.3.3]
    ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin.
    • CTP has half the activity of ATP.
    		 2 W8HBN1 W8HBN1
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