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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63070: 5-aminolevulinate synthase, erythroid-specific, mi...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
5-aminolevulinate synthase. [EC: 2.3.1.37]
Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO(2).
    		 5250 A0A010QIE2 A0A010QIE2 A0A011UBZ7 A0A011UBZ7 A0A011UM09 A0A011UM09 A0A013VRM8 A0A013VRM8 A0A014NZ11 A0A014NZ11
    (5240 more...)
    8-amino-7-oxononanoate synthase. [EC: 2.3.1.47]
    Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].
    • The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis.
    • Pimeloyl-CoA can be used with lower efficiency.
    		 4 A0A1E7ZNQ0 A0A1E7ZNQ0 A0A1E8A5C7 A0A1E8A5C7
    Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
    ATP + a protein = ADP + a phosphoprotein.
    • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
    • Formerly EC 2.7.1.37 and EC 2.7.1.70.
    		 2 A0A075ATY3 A0A075ATY3
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