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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 62900: Decarboxylase (Lysine, ornithine, arginine)

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Lysine decarboxylase. [EC: 4.1.1.18]
L-lysine = cadaverine + CO(2).
  • Also acts on 5'-hydroxy-L-lysine.
 2068 A0A014MCF2 A0A014MCF2 A0A023V7A2 A0A023V7A2 A0A023YSR4 A0A023YSR4 A0A023Z6E9 A0A023Z6E9 A0A024KM24 A0A024KM24
(2058 more...)
Ornithine decarboxylase. [EC: 4.1.1.17]
L-ornithine = putrescine + CO(2).
    		 1548 A0A017I9G9 A0A017I9G9 A0A023Z2D6 A0A023Z2D6 A0A024KQI2 A0A024KQI2 A0A024L5B2 A0A024L5B2 A0A024LAL1 A0A024LAL1
    (1538 more...)
    Arginine decarboxylase. [EC: 4.1.1.19]
    L-arginine = agmatine + CO(2).
      		 796 A0A017I9N4 A0A017I9N4 A0A023V7D1 A0A023V7D1 A0A023Z6P3 A0A023Z6P3 A0A024KNF1 A0A024KNF1 A0A025C2L9 A0A025C2L9
      (786 more...)
      2-oxoglutarate decarboxylase. [EC: 4.1.1.71]
      2-oxoglutarate = succinate semialdehyde + CO(2).
      • Highly specific.
      		 2 V6MHG4 V6MHG4
      Cu(2+)-exporting ATPase. [EC: 3.6.3.4]
      ATP + H(2)O + Cu(2+)(Side 1) = ADP + phosphate + Cu(2+)(Side 2).
      • A P-type ATPase that undergoes covalent phosphorylation during the transport cycle.
      • The enzyme from the termophilic bacterium Archaeoglobus fulgidus is involved in copper extrusion from the cell.
      		 2 F5RVI8 F5RVI8
      Adenosylhomocysteine nucleosidase. [EC: 3.2.2.9]
      (1) S-adenosyl-L-homocysteine + H(2)O = S-(5-deoxy-D-ribos-5-yl)-L- homocysteine + adenine. (2) S-methyl-5'-thioadenosine + H(2)O = 5-methyl-5-thio-D-ribose + adenine.
        		 2 A4MVB9 A4MVB9
        Ornithine carbamoyltransferase. [EC: 2.1.3.3]
        Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
        • The plant enzyme also catalyzes the reactions of EC 2.1.3.6, EC 2.7.2.2 and EC 3.5.3.12, thus acting as putrescine synthase, converting agmatine and ornithine into putrescine and citrulline respectively.
        		 2 A5UHB0 A5UHB0
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