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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 62777: Diaminobutyrate--2-oxoglutarate transaminase (Diam...

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Diaminobutyrate--2-oxoglutarate transaminase. [EC: 2.6.1.76]
L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate.
  • Differs from EC 2.6.1.46, which has pyruvate as the amino-group acceptor.
  • This is the first enzyme in the ectoine biosynthesis pathway, the other enzymes involved being EC 2.3.1.178 and EC 4.2.1.108.
 1755 A0A009ETH4 A0A009GAI7 A0A009HGK0 A0A009I3D2 A0A009INR5 A0A009KB47 A0A009KLP3 A0A009KRA0 A0A009N3J8 A0A009Q3A5
(1745 more...)
Diaminobutyrate--pyruvate transaminase. [EC: 2.6.1.46]
L-2,4-diaminobutanoate + pyruvate = L-aspartate 4-semialdehyde + L-alanine.
    		 102 A0A059MS24 A0A063Y356 A0A063Y5F3 A0A081FW52 A0A090P3K9 A0A094WHJ3 A0A095VRD6 A0A095VUP1 A0A0A0BGL9 A0A0A0BGS5
    (92 more...)
    4-aminobutyrate--2-oxoglutarate transaminase. [EC: 2.6.1.19]
    4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.
    • Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.
    		 8 A0A156WCP4 A0A181D7G3 A0A1M5V5J5 E0SIE8 Q21K75 U1BCM3 V3DFQ1 W7NVU6
    Acetylornithine transaminase. [EC: 2.6.1.11]
    N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
    • Also acts on L-ornithine and N(2)-succinyl-L-ornithine.
    		 6 A0A0T8L7L6 A0A0X9J8C8 A0A0Y0BI95 D0HCR3 E1X6A3 S6JKG2
    Glutamate-1-semialdehyde 2,1-aminomutase. [EC: 5.4.3.8]
    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.
      		 3 A0A151A9B6 K5C926 M5SC11
      Diaminobutyrate decarboxylase. [EC: 4.1.1.86]
      L-2,4-diaminobutanoate = propane-1,3-diamine + CO(2).
      • N(4)-acetyl-L-2,4-diaminobutanoate, 2,3-diaminopropanoate, ornithine and lysine are not substrates.
      • In Acinetobacter baumannii it is cotranscribed with the neighboring dat gene that encodes EC 2.6.1.76, which can supply the substrate for the decarboxylase.
      		 2 A0A090P4F9 A0A090R3G5
      Succinylornithine transaminase. [EC: 2.6.1.81]
      N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate.
      • Also acts on N(2)-acetyl-L-ornithine and L-ornithine, but more slowly.
      • In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, EC 2.6.1.11 and EC 2.6.1.13 activities are catalyzed by the same enzyme, but this is not the case in all species.
      • This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine.
      • This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA.
      • The five enzymes involved in this pathway are EC 2.3.1.109, EC 3.5.3.23, EC 2.6.1.81, EC 1.2.1.71 and EC 3.5.1.96.
      		 1 D0HCR3
      Succinyldiaminopimelate transaminase. [EC: 2.6.1.17]
      N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2- L-amino-6-oxoheptanedioate + L-glutamate.
        		 1 D0HCR3
        Ectoine synthase. [EC: 4.2.1.108]
        N(4)-acetyl-L-2,4-diaminobutanoate = L-ectoine + H(2)O.
        • Ectoine is an osmoprotectant that is found in halophilic eubacteria.
        • This enzyme is part of the ectoine biosynthesis pathway and only acts in the direction of ectoine formation.
        • Cf. EC 3.5.4.44.
        		 1 A0A1C5CTR2
        Ornithine aminotransferase. [EC: 2.6.1.13]
        L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
          		 1 D0HCR3
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