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CATH Superfamily 3.40.640.10

Type I PLP-dependent aspartate aminotransferase-like (Major domain)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Type I PLP-dependent aspartate aminotransferase-like (Major domain)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19536: N-succinyl-L,L-diaminopimelate aminotransferase al...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Succinyldiaminopimelate transaminase. [EC: 2.6.1.17]
N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2- L-amino-6-oxoheptanedioate + L-glutamate.
    		 40 A0A061D3F1 A0A067AG16 A0A087FA09 A0A098FT42 A0A0A1HSJ2 A0A0D6RW58 A0A0E3GZV3 A0A0F7A6C9 A0A0M9GJL0 A0A0N0EZB6
    (30 more...)
    LL-diaminopimelate aminotransferase. [EC: 2.6.1.83]
    LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5- tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H(2)O.
    • In vivo, the reaction occurs in the opposite direction to that shown above.
    • This is one of the final steps in the lysine biosynthesis pathway of plants (ranging from mosses to flowering plants).
    • Meso-diaminoheptanedioate, an isomer of LL-2,6-diaminoheptanedioate, and the structurally related compounds lysine and ornithine are not substrates.
    • 2-oxoglutarate cannot be replaced by oxaloacetate or pyruvate.
    • It is not yet known if the substrate of the biosynthetic reaction is the cyclic or acyclic form of tetrahydropyridine-2,6-dicarboxylate.
    		 26 A0A080VRS3 A0A0B7D3V0 A0A0D0TGP1 A0A0F6UAU2 A0A0H2ZES5 A0A0P1D880 A0A0Q8YBG2 A0A0R3CCA2 A0A0S4HRU2 A0A0S4IBS9
    (16 more...)
    Aspartate transaminase. [EC: 2.6.1.1]
    L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
    • Also acts on L-tyrosine, L-phenylalanine and L-tryptophan.
    • This activity can be formed from EC 2.6.1.57 by controlled proteolysis.
    		 2 A0A0T8LFK6 F2N2M7
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