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CATH Superfamily 3.40.630.30

Gcn5-related N-acetyltransferase (GNAT)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 70624: Polyketide synthase/nonribosomal peptide synthetas...

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
(R)-amidase. [EC: 3.5.1.100]
(1) (R)-piperazine-2-carboxamide + H(2)O = (R)-piperazine-2-carboxylate + NH(3). (2) Beta-alaninamide + H(2)O = beta-alanine + NH(3).
  • In addition (R)-piperidine-3-carboxamide is hydrolyzed to (R)- piperidine-3-carboxylic acid and NH(3), and (R)-N-tert- butylpiperazine-2-carboxamide is hydrolyzed to (R)-piperazine-2- carboxylic acid and tert-butylamine with lower activity.
  • The enzyme does not act on the other amide substrates which are hydrolyzed by EC 3.5.1.4 (amidase).
 60 A0A063XHU3 A0A063XHU3 A0A0B0QA27 A0A0B0QA27 A0A0H4R5A6 A0A0H4R5A6 A0A0K6JU20 A0A0K6JU20 A0A0K6KID0 A0A0K6KID0
(50 more...)
Nitrilase. [EC: 3.5.5.1]
A nitrile + 2 H(2)O = a carboxylate + NH(3).
  • Acts on a wide range of aromatic nitriles including (indol-3- yl)acetonitrile, and also on some aliphatic nitriles, and on the corresponding acid amides (cf. EC 4.2.1.84).
 14 A0A0D7XT91 A0A0D7XT91 A0A0E1LL55 A0A0E1LL55 A0A1D9PHE2 A0A1D9PHE2 A2RH43 A2RH43 A7Z2T9 A7Z2T9
(4 more...)
Amidase. [EC: 3.5.1.4]
A monocarboxylic acid amide + H(2)O = a monocarboxylate + NH(3).
    		 4 A0A1B6BGL8 A0A1B6BGL8 A0A1G4LNZ5 A0A1G4LNZ5
    Aralkylamine N-acetyltransferase. [EC: 2.3.1.87]
    Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine.
    • Narrow specificity toward 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine.
    • This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4).
    • Differs from EC 2.3.1.5.
    		 2 Q94521 Q94521
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