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CATH Superfamily 3.40.630.30

Gcn5-related N-acetyltransferase (GNAT)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 70517: N-alpha-acetyltransferase 60

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histone acetyltransferase. [EC: 2.3.1.48]
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
  • A group of enzymes acetylating histones.
  • Several of the enzymes can also acetylate lysines in other proteins.
 18 A3KPA3 A3KPA3 A8E5V7 A8E5V7 M5FJV6 M5FJV6 Q17QK9 Q17QK9 Q3MHC1 Q3MHC1
(8 more...)
N-terminal methionine N(alpha)-acetyltransferase NatF. [EC: 2.3.1.259]
Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA.
  • N-terminal-acetylases (NATs) catalyze the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.
  • This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis.
  • NatF is found only in higher eukaryotes, and is absent from yeast.
  • Unlike other Nat systems the enzyme is located in the Golgi apparatus.
  • It faces the cytosolic side of intracellular membranes, and specifically acetylates transmembrane proteins whose N termini face the cytosol.
  • NatF targets N-terminal L-methionine residues attached to Lys, Ser, Val, Leu, Gln, Ile, Tyr and Thr residues.
  • Formerly EC 2.3.1.88.
 16 A3KPA3 A3KPA3 A8E5V7 A8E5V7 M5FJV6 M5FJV6 Q17QK9 Q17QK9 Q3MHC1 Q3MHC1
(6 more...)
Transferred entry: 2.3.1.254, 2.3.1.255, 2.3.1.256, 2.3.1.257, 2.3.1.258 and 2.3.1.259. [EC: 2.3.1.88]
    		2 G3I034 G3I034
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