The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 70410: N(Alpha)-acetyltransferase 50, NatE catalytic subu...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptide alpha-N-acetyltransferase activity GO:0004596
Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.
6 Q0IIJ0 (/ISS) Q5RF28 (/ISS) Q5XGA9 (/ISS) Q6DBY2 (/ISS) Q6GP53 (/ISS) Q6PGB6 (/ISS)
H4 histone acetyltransferase activity GO:0010485
Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4.
6 Q0IIJ0 (/ISS) Q5RF28 (/ISS) Q5XGA9 (/ISS) Q6DBY2 (/ISS) Q6GP53 (/ISS) Q6PGB6 (/ISS)
Peptidyl-lysine acetyltransferase activity GO:0052858
Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine.
6 Q0IIJ0 (/ISS) Q5RF28 (/ISS) Q5XGA9 (/ISS) Q6DBY2 (/ISS) Q6GP53 (/ISS) Q6PGB6 (/ISS)
Peptide alpha-N-acetyltransferase activity GO:0004596
Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.
2 Q9GZZ1 (/IDA) Q9NHD5 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q6PGB6 (/IPI) Q9GZZ1 (/IPI)
Peptide alpha-N-acetyltransferase activity GO:0004596
Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.
1 Q6PGB6 (/ISO)
N-acetyltransferase activity GO:0008080
Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
1 Q9NHD5 (/ISM)
N-acetyltransferase activity GO:0008080
Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
1 Q9NHD5 (/ISS)
H4 histone acetyltransferase activity GO:0010485
Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4.
1 Q9GZZ1 (/IDA)
H4 histone acetyltransferase activity GO:0010485
Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4.
1 Q6PGB6 (/ISO)
Peptidyl-lysine acetyltransferase activity GO:0052858
Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine.
1 Q9GZZ1 (/IDA)
Peptidyl-lysine acetyltransferase activity GO:0052858
Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine.
1 Q6PGB6 (/ISO)
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
1 Q9P6R8 (/ISM)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic sister chromatid cohesion, centromeric GO:0071962
The cell cycle process in which centromeres of sister chromatids are joined during mitosis.
6 Q0IIJ0 (/ISS) Q5RF28 (/ISS) Q5XGA9 (/ISS) Q6DBY2 (/ISS) Q6GP53 (/ISS) Q6PGB6 (/ISS)
N-terminal protein amino acid acetylation GO:0006474
The acetylation of the N-terminal amino acid of proteins.
2 Q6PGB6 (/TAS) Q9GZZ1 (/TAS)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q9NHD5 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q6DBY2 (/IMP)
N-terminal protein amino acid acetylation GO:0006474
The acetylation of the N-terminal amino acid of proteins.
1 Q9NHD5 (/IDA)
Mitotic sister chromatid cohesion GO:0007064
The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.
1 Q9NHD5 (/IMP)
SnoRNA metabolic process GO:0016074
The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA.
1 Q9P6R8 (/NAS)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
1 Q9NHD5 (/IMP)
MRNA cis splicing, via spliceosome GO:0045292
The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
1 Q9P6R8 (/TAS)
Lateral inhibition GO:0046331
Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.
1 Q9NHD5 (/IMP)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
1 Q9NHD5 (/IMP)
Mitotic sister chromatid cohesion, centromeric GO:0071962
The cell cycle process in which centromeres of sister chromatids are joined during mitosis.
1 Q9GZZ1 (/IDA)
Mitotic sister chromatid cohesion, centromeric GO:0071962
The cell cycle process in which centromeres of sister chromatids are joined during mitosis.
1 Q6PGB6 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 Q0IIJ0 (/ISS) Q5RF28 (/ISS) Q5XGA9 (/ISS) Q6DBY2 (/ISS) Q6GP53 (/ISS) Q6PGB6 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 Q0IIJ0 (/ISS) Q5RF28 (/ISS) Q5XGA9 (/ISS) Q6DBY2 (/ISS) Q6GP53 (/ISS) Q6PGB6 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9GZZ1 (/IDA) Q9P6R8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9GZZ1 (/IDA) Q9NHD5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6PGB6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q6PGB6 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9NHD5 (/IDA)
Cohesin complex GO:0008278
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
1 Q9NHD5 (/IDA)
Protein acetyltransferase complex GO:0031248
A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule.
1 Q9NHD5 (/IPI)
NatA complex GO:0031415
A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.
1 Q9NHD5 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9GZZ1 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q6PGB6 (/ISO)