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CATH Superfamily 3.40.630.30

Gcn5-related N-acetyltransferase (GNAT)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 70322: Related to MAK3 N-acetyltransferase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Transferred entry: 2.3.1.254, 2.3.1.255, 2.3.1.256, 2.3.1.257, 2.3.1.258 and 2.3.1.259. [EC: 2.3.1.88]
    		7 A0A0B2Q219 B7QNQ0 B9RGX2 E0VIN5 I1N4X7 V5IEQ0 W1QIN3
    N-terminal methionine N(alpha)-acetyltransferase NatC. [EC: 2.3.1.256]
    (1) Acetyl-CoA + an N-terminal-L-methionyl-L-leucyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA. (2) Acetyl-CoA + an N-terminal-L-methionyl-L-isoleucyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA. (3) Acetyl-CoA + an N-terminal-L-methionyl-L-phenylalanyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA. (4) Acetyl-CoA + an N-terminal-L-methionyl-L-tryptophyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA. (5) Acetyl-CoA + an N-terminal-L-methionyl-L-tyrosinyl-[protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-L-tyrosinyl-[protein] + CoA.
    • N-terminal-acetylases (NATs) catalyze the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.
    • This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing.
    • The NatC complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to bulky hydrophobic residues at the second position, including Leu, Ile, Phe, Trp, and Tyr residues.
    • Formerly EC 2.3.1.88.
    		 7 N1P245 O74311 O80438 Q03503 Q0IHH1 Q147X3 Q8CES0
    Ribosomal-protein-alanine N-acetyltransferase. [EC: 2.3.1.128]
    Acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine.
    • A groups of enzymes in Escherichia coli that acetylate the N-terminal alanine residues of specific ribosomal proteins.
    		 2 A0A0J5PUK6 Q4WXL6
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