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CATH Superfamily 3.40.630.30

Gcn5-related N-acetyltransferase (GNAT)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 69903: Aminoacyltransferase FemB

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-triglycine)-D-alanyl- D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase. [EC: 2.3.2.18]
MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho- ditrans,octacis-undecaprenyl-GlcNAc + 2 glycyl-tRNA = MurNAc-L-Ala-D- isoglutaminyl-L-Lys-(N(6)-penta-Gly)-D-Ala-D-Ala-diphospho- ditrans,octacis-undecaprenyl-GlcNAc + 2 tRNA.
  • This Staphylococcus aureus enzyme catalyzes the successive transfer of two glycine moieties from charged tRNAs to MurNAc-L-Ala-D- isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho- ditrans,octacis-undecaprenyl-GlcNAc, attaching them to the three glycine molecules that were previously attached to the N(6) of the L-lysine at position 3 of the pentapeptide by EC 2.3.2.16 (FemX) and EC 2.3.2.17 (FemA).
  • This is the last step in the synthesis of the pentaglycine interpeptide bridge that is used in this organism for the crosslinking of different glycan strands to each other.
 60 A0A077UZL4 A0A0D1JZ81 A0A0E0VNQ7 A0A0E1AI15 A0A0E1VHQ0 A0A0E1XG48 A0A0H2XHG6 A0A0H3K8J6 A0A0U1DZI3 A0A0U1MZ25
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