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CATH Superfamily 3.40.630.30

Gcn5-related N-acetyltransferase (GNAT)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 69868: Acyl-homoserine-lactone synthase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acyl-homoserine-lactone synthase. [EC: 2.3.1.184]
An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine = [acyl-carrier- protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone.
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • N-(3-oxohexanoyl)-[acyl-carrier-protein] and hexanoyl-[acyl-carrier- protein] are the best substrates.
  • The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier-protein] rather than from fatty-acid degradation through acyl-CoA.
  • S-adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone.
 17 A0A023PY52 A0A059WLG8 A0A0D0RMC9 A0A125S8P1 A0A1H1N5F4 A0A1H1QT38 A0A1H1RBF9 B6V854 E3UVC4 H2DFH1
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