The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Peptidase C15, pyroglutamyl peptidase I-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 858: Pyrrolidone-carboxylate peptidase 2

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyroglutamyl-peptidase I. [EC: 3.4.19.3]
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
  • Inhibited by thiol-blocking reagents.
  • Belongs to peptidase family C15.
  • Formerly EC 3.4.11.8.
2833 A0A010PKL6 A0A011RLG4 A0A014LGA2 A0A014M647 A0A017RRF7 A0A022FSQ9 A0A022ME32 A0A022N5T1 A0A022PLV2 A0A023DFG1
(2823 more...)
Dephospho-CoA kinase. [EC: 2.7.1.24]
ATP + 3'-dephospho-CoA = ADP + CoA.
    1 A0A021VW32