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CATH Superfamily 3.40.630.20

Peptidase C15, pyroglutamyl peptidase I-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Peptidase C15, pyroglutamyl peptidase I-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 564: Pyroglutamyl-peptidase 1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyroglutamyl-peptidase I. [EC: 3.4.19.3]
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
  • Inhibited by thiol-blocking reagents.
  • Belongs to peptidase family C15.
  • Formerly EC 3.4.11.8.
 7 A0A061IJS5 G1R258 H2NY33 H2QFT0 Q76IC5 Q9ESW8 Q9NXJ5