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CATH Superfamily 3.40.605.10

Aldehyde Dehydrogenase; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 304: Fused aldehyde dehydrogenase enoyl-CoA hydratase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (NADP(+)). [EC: 1.2.1.77]
Cis-3,4-dehydroadipyl-CoA semialdehyde + NADP(+) + H(2)O = cis-3,4- dehydroadipyl-CoA + NADPH.
  • This enzyme catalyzes a step in the aerobic benzoyl-coenzyme A catabolic pathway in Azoarcus evansii and Burkholderia xenovorans.
  • Formerly EC 1.2.1.n1.
 39 A0A027THV2 A0A027ZPQ6 A0A028E061 A0A066QC17 A0A0A8U7E3 A0A0E0TXX2 A0A0E0Y182 A0A0F3T8J2 A0A0H0CSE4 A0A0H0EPI7
(29 more...)
Oxepin-CoA hydrolase. [EC: 3.3.2.12]
2-oxepin-2(3H)-ylideneacetyl-CoA + H(2)O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde.
  • The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyzes EC 1.17.1.7.
  • Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway.
  • The enzyme from Escherichia coli also exhibits enoyl-CoA hydratase activity utilizing crotonyl-CoA as a substrate.
  • Formerly EC 3.7.1.16.
 29 A0A070VA51 A0A074IKC5 A0A0A0F843 A0A0E1CF00 A0A0E1LWY3 A0A0E1SSD9 A0A0H3GSM6 A0A0J2G7R3 A0A0M1T9C1 A0A125X4H0
(19 more...)
3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase. [EC: 1.2.1.91]
3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP(+) + H(2)O = 3-oxo-5,6- dehydrosuberyl-CoA + NADPH.
  • The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyzes EC 3.3.2.12.
  • Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway.
  • Formerly EC 1.2.1.91.
 23 A0A070VA51 A0A074IKC5 A0A0A0F843 A0A0E1LWY3 A0A0E1SSD9 A0A125X4H0 A0A1J0HAX3 D7XYZ4 D8BSB9 E3PLB8
(13 more...)
Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
  • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
  • Formerly EC 1.1.1.70.
 20 A0A023YXK5 A0A025CBP8 A0A085AII5 A0A085H6D4 A0A085HT90 A0A0F3U980 A0A0K4X4R4 A0A0M3H5U0 A0A157TQJ9 A0A198GI01
(10 more...)
Transferred entry: 1.2.1.91. [EC: 1.17.1.7]
    		6 A0A0E1CF00 A0A0H3GSM6 A0A0J2G7R3 A0A0M1T9C1 A0A1L6IYD4 W8UIT6
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