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CATH Superfamily 3.40.605.10

Aldehyde Dehydrogenase; Chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15061: Aldehyde dehydrogenase, ethanolamine utilization p...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Retinal dehydrogenase. [EC: 1.2.1.36]
Retinal + NAD(+) + H(2)O = retinoate + NADH.
  • Acts on both the 11-trans- and 13-cis-forms of retinal.
 24 A0A024L0U3 A0A0A0FB95 A0A0E0U1V3 A0A0E1M002 A0A0M7P169 A0A0P8AIK3 A0A142V0Z4 A0A1J0HDT4 D8AWD2 D8B512
(14 more...)
Acetaldehyde dehydrogenase (acetylating). [EC: 1.2.1.10]
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH.
  • Also acts, more slowly, on glycolaldehyde, propanal and butanal.
  • In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39.
  • The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87.
  • Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols.
  • NADP(+) can replace NAD(+) but the rate of reaction is much slower.
 9 A0A064DNU9 A0A0A1RY91 A0A1C3P422 A0A1G4E534 E0SC95 G7LNG9 I6CIS6 I6DWZ6 I6HES7
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