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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36359: Transketolase, N-terminal (Sedoheptulose-7-phospha...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Transketolase. [EC: 2.2.1.1]
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
  • Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH.
  • The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.
 263 A0A023GNW6 A0A031WJ19 A0A044R7T0 A0A060VMK2 A0A072XDV7 A0A072YP42 A0A087U756 A0A087XJ72 A0A087XJ98 A0A096MXL0
(253 more...)
DNA-directed DNA polymerase. [EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
  • Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • Cannot initiate a chain de novo.
  • Requires a primer which may be DNA or RNA.
  • See also EC 2.7.7.49.
 5 A0A0F4VW49 A0A0F4WLN6 A0A0F4WM65 C4ICX1 N9YSS5
Transaldolase. [EC: 2.2.1.2]
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.
    		 3 A0A1C7AEY5 D5C1T7 D8K9Q0
    1-deoxy-D-xylulose-5-phosphate synthase. [EC: 2.2.1.7]
    Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
    • The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
    • Formerly EC 4.1.3.37.
    		 1 A0A098B809
    Calcium/calmodulin-dependent protein kinase. [EC: 2.7.11.17]
    ATP + a protein = ADP + a phosphoprotein.
    • Requires calmodulin.
    • A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein.
    • Not identical with EC EC 2.7.11.18 or EC 2.7.11.26.
    • Formerly EC 2.7.1.120 and EC 2.7.1.123.
    		 1 G0R2J9