View in Gene3D

CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 36350: Pyruvate decarboxylase isozyme 1

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Indolepyruvate decarboxylase. [EC: 4.1.1.74]
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).
  • More specific than EC 4.1.1.1.
 368 A0A060V9P3 A0A060V9P3 A0A066NVY0 A0A066NVY0 A0A068Z305 A0A068Z305 A0A085A9J4 A0A085A9J4 A0A085G8F6 A0A085G8F6
(358 more...)
Pyruvate decarboxylase. [EC: 4.1.1.1]
A 2-oxo acid = an aldehyde + CO(2).
  • Also catalyzes acyloin formation.
 262 A0A060TB88 A0A060TB88 A0A085A9J4 A0A085A9J4 A0A085G8F6 A0A085G8F6 A0A085G8U9 A0A085G8U9 A0A085GVI9 A0A085GVI9
(252 more...)
Phenylpyruvate decarboxylase. [EC: 4.1.1.43]
Phenylpyruvate = phenylacetaldehyde + CO(2).
  • Also acts on (indol-3-yl)pyruvate.
 14 A0A0L8VLD5 A0A0L8VLD5 A7A0U9 A7A0U9 B3LT15 B3LT15 E7KFE4 E7KFE4 E7LXD6 E7LXD6
(4 more...)
Acetolactate synthase. [EC: 2.2.1.6]
2 pyruvate = 2-acetolactate + CO(2).
  • The reaction shown is in the pathway of biosynthesis of valine.
  • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
  • Formerly EC 4.1.3.18.
 2 A0A0T8G9F3 A0A0T8G9F3
Thiol oxidase. [EC: 1.8.3.2]
2 R'C(R)SH + O(2) = R'C(R)S-S(R)CR' + H(2)O(2).
  • R may be =S or =O, or a variety of other groups.
  • The enzyme is not specific for R'.
 2 G0SB10 G0SB10