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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36318: Pyruvate synthase, subunit beta

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyruvate synthase. [EC: 1.2.7.1]
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
 124 A0A062UWX7 A0A090I2J1 A0A0A6N1Y9 A0A0E3H8K6 A0A0E3KPZ5 A0A0E3KRD8 A0A0E3L020 A0A0E3L3R8 A0A0E3L9P7 A0A0E3LEF7
(114 more...)
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). [EC: 1.2.7.7]
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+).
  • Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo- pentanoate, 2-oxobutyrate and 3-methylthiopropanamine.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.3.
 25 A0A075LTJ0 A0A097QRP3 A0A0Q2M5U9 A0A0S1XDT6 A0A0S1XDU0 A0A0S8I3L7 A0A0S8K6H6 A0A0U3HHP7 A0A0X1KJD8 A0A117L1T2
(15 more...)
Phenylglyoxylate dehydrogenase (acylating). [EC: 1.2.1.58]
Phenylglyoxylate + NAD(+) + CoA = benzoyl-S-CoA + CO(2) + NADH.
  • The enzyme from Azoarcus evansii is specific for phenylglyoxylate.
  • 2-oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate.
  • Also reduces viologen dyes.
 1 Q8L3A9