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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36197: Pyruvate synthase, subunit alpha

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyruvate synthase. [EC: 1.2.7.1]
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
 86 A0A062V809 A0A089Z9W1 A0A090I281 A0A0A6N4P4 A0A0E3LGD9 A0A0E3NCR5 A0A0E3NI73 A0A0E3NMQ3 A0A0E3NW06 A0A0E3P081
(76 more...)
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). [EC: 1.2.7.7]
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+).
  • Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo- pentanoate, 2-oxobutyrate and 3-methylthiopropanamine.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.3.
 17 A0A0S1XDR1 A0A0U3R7Q7 A0A150ILX2 A0A150IRX2 A0A150IUK5 A0A150J245 A0A150JEJ0 A0A150JJX7 A0A150JL20 A0A160VSM4
(7 more...)
Phenylglyoxylate dehydrogenase (acylating). [EC: 1.2.1.58]
Phenylglyoxylate + NAD(+) + CoA = benzoyl-S-CoA + CO(2) + NADH.
  • The enzyme from Azoarcus evansii is specific for phenylglyoxylate.
  • 2-oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate.
  • Also reduces viologen dyes.
 1 Q8L3B1
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