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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 35969: 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrola...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing). [EC: 3.7.1.22]
3D-3,5/4-trihydroxycyclohexa-1,2-dione + H(2)O = 5-deoxy-D-glucuronate.
  • The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol degradation pathway leading to acetyl-CoA.
  • Formerly EC 3.7.1.n2.
 395 A0A023CPH0 A0A024P4R6 A0A037Z912 A0A060HYE6 A0A060LS55 A0A066PJ40 A0A072XBF0 A0A072YE29 A0A072YQN6 A0A077J662
(385 more...)
Acetolactate synthase. [EC: 2.2.1.6]
2 pyruvate = 2-acetolactate + CO(2).
  • The reaction shown is in the pathway of biosynthesis of valine.
  • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
  • Formerly EC 4.1.3.18.
 32 A0A075KG71 A0A077MTC8 A0A077NLE9 A0A077NX31 A0A077PCS6 A0A077PYN4 A0A077QIH5 A0A083ZJG6 A0A0A8NT30 A0A0D5M037
(22 more...)
Transferred entry: 3.7.1.22. [EC: 3.7.1.n2]
    		17 A0A021XG47 A0A0M2A9P6 A0A0M2AQX6 A0A0Y4AS21 A0A125W243 A0A181XUR1 A0A1J6Y6N7 C7VAA4 E0HCJ8 E2YVW5
    (7 more...)
    Fumarylacetoacetase. [EC: 3.7.1.2]
    4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate.
    • Also acts on other 3,5- and 2,4-dioxo acids.
    		 2 S0ANE5 S4YPM3
    Pyruvate oxidase. [EC: 1.2.3.3]
    Pyruvate + phosphate + O(2) = acetyl phosphate + CO(2) + H(2)O(2).
    • Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin.
    • FADH is reoxidized by O(2) to yield H(2)O(2) and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate.
    		 1 A0A1A7TP81