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CATH Superfamily 3.40.50.970

Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11434: 2-oxoglutarate oxidoreductase, beta subunit

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-oxoglutarate synthase. [EC: 1.2.7.3]
2-oxoglutarate + CoA + 2 oxidized ferredoxin = succinyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
  • Highly specific for 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.7.
  • Formerly EC 1.2.7.9.
 94 A0A023PB33 A0A084J4B3 A0A0A3WP42 A0A0B5RA61 A0A0B5RXU2 A0A0D0GN21 A0A0D1NKA1 A0A0F6FUW5 A0A0F6J140 A0A0G3E8T0
(84 more...)
Pyruvate synthase. [EC: 1.2.7.1]
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
 89 A0A023PB33 A0A063CH75 A0A0A3WP42 A0A0B5RA61 A0A0B6BGX3 A0A0D0GN21 A0A0D1NKA1 A0A0F5RR27 A0A0F6FUW5 A0A0F6J140
(79 more...)