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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4798: GDP-mannose 4,6-dehydratase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
GDP-L-fucose synthase. [EC: 1.1.1.271]
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH.
  • Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.
 746 A0A017IFM3 A0A017IFM3 A0A023Z042 A0A023Z042 A0A024KX19 A0A024KX19 A0A024KX67 A0A024KX67 A0A024L229 A0A024L229
(736 more...)
GDP-mannose 4,6-dehydratase. [EC: 4.2.1.47]
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.
  • Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose.
  • In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.
 6 E9YBZ6 E9YBZ6 F8X9S8 F8X9S8 W8SMH7 W8SMH7