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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 292195: Shikimate dehydrogenase (NADP(+))

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Shikimate dehydrogenase. [EC: 1.1.1.25]
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
  • NAD(+) cannot replace NADP(+).
  • In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
 3118 A0A010NMI8 A0A010NMI8 A0A010RPR3 A0A010RPR3 A0A010RS62 A0A010RS62 A0A014MQV8 A0A014MQV8 A0A017SZJ3 A0A017SZJ3
(3108 more...)
3-dehydroquinate dehydratase. [EC: 4.2.1.10]
3-dehydroquinate = 3-dehydroshikimate + H(2)O.
    		 42 A0A0B2P481 A0A0B2P481 A0A0B2PJB7 A0A0B2PJB7 A0A0B2QJX5 A0A0B2QJX5 A0A178VBC4 A0A178VBC4 B9REX9 B9REX9
    (32 more...)
    Quinate dehydrogenase. [EC: 1.1.1.24]
    Quinate + NAD(+) = 3-dehydroquinate + NADH.
    • The enzyme is specific for quinate as substrate; phenylpyruvate, phenylalanine, cinnamate and shikimate will not act as substrates.
    • NAD(+) cannot be replaced by NADP(+).
    		 20 A0A072Z5G5 A0A072Z5G5 A0A0E0UQN5 A0A0E0UQN5 A0A0F6Z3Y2 A0A0F6Z3Y2 A0A0S2T1T5 A0A0S2T1T5 A4QB65 A4QB65
    (10 more...)
    Quinate/shikimate dehydrogenase. [EC: 1.1.1.282]
    (1) L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. (2) Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H.
    • This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, in that it can use both quinate and shikimate as substrate and either NAD(+) or NADP(+) as acceptor.
    		 18 A0A085G6L7 A0A085G6L7 A0A085GXW4 A0A085GXW4 A0A085HXJ3 A0A085HXJ3 A0A085JCT2 A0A085JCT2 A0A198GX37 A0A198GX37
    (8 more...)
    Shikimate kinase. [EC: 2.7.1.71]
    ATP + shikimate = ADP + shikimate 3-phosphate.
      		 4 A0A0J1F5C5 A0A0J1F5C5 A0A0W8FJ62 A0A0W8FJ62
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