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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291958: Chorismate mutase I / Cyclohexadienyl dehydrogenas...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Prephenate dehydrogenase. [EC: 1.3.1.12]
Prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH.
  • This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate.
 428 A0A024KPQ9 A0A024KPQ9 A0A024LAY5 A0A024LAY5 A0A026UEG2 A0A026UEG2 A0A027ZLB4 A0A027ZLB4 A0A028DYD4 A0A028DYD4
(418 more...)
Chorismate mutase. [EC: 5.4.99.5]
Chorismate = prephenate.
    		 208 A0A024LAY5 A0A024LAY5 A0A059I5B3 A0A059I5B3 A0A068R9W0 A0A068R9W0 A0A069XD49 A0A069XD49 A0A070SWZ0 A0A070SWZ0
    (198 more...)
    Arogenate dehydrogenase (NADP(+)). [EC: 1.3.1.78]
    L-arogenate + NADP(+) = L-tyrosine + NADPH + CO(2).
    • Arogenate dehydrogenases may utilize NAD(+) (EC 1.3.1.43), NADP(+) (EC 1.3.1.78), or both (EC 1.3.1.79).
    • NADP(+)-dependent enzymes usually predominate in higher plants.
    • The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 and the TyrAAT1 isoform of the plant Arabidopsis thaliana cannot use prephenate as a substrate, while the Arabidopsis isoform TyrAAT2 can use it very poorly.
    		 4 Q944B6 Q944B6 Q9LMR3 Q9LMR3
    Arogenate dehydrogenase. [EC: 1.3.1.43]
    L-arogenate + NAD(+) = L-tyrosine + NADH + CO(2).
    • Arogenate dehydrogenases may utilize NAD(+) (EC 1.3.1.43), NADP(+) (EC 1.3.1.78), or both (EC 1.3.1.79).
    • NAD(+)-specific enzymes have been reported from some bacteria and plants.
    • Some enzymes also possess the activity of EC 1.3.1.12.
    		 2 A0A1L9F2U9 A0A1L9F2U9
    Prephenate dehydrogenase (NADP(+)). [EC: 1.3.1.13]
    Prephenate + NADP(+) = 4-hydroxyphenylpyruvate + CO(2) + NADPH.
      		 2 A0A1L9F2U9 A0A1L9F2U9