View in Gene3D

CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 291666: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. [EC: 3.2.2.6]
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
  • This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC 2.4.99.20.
  • Cf. EC 3.2.2.5.
 26 F6QEE7 F6QEE7 G7P5B0 G7P5B0 P28907 P28907 P29241 P29241 P56528 P56528
(16 more...)
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase. [EC: 2.4.99.20]
NADP(+) + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide.
  • This multiunctional enzyme catalyzes both the removal of nicotinamide from NADP(+), forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP(+), a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC 3.2.2.6.
 20 F6QEE7 F6QEE7 G7P5B0 G7P5B0 P28907 P28907 P29241 P29241 P56528 P56528
(10 more...)
NAD(+) glycohydrolase. [EC: 3.2.2.5]
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
  • This enzyme catalyzes the hydrolysis of NAD(+), without associated ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
  • The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis.
  • The enzyme from the venom of the snake Agkistrodon acutus also catalyzes EC 3.6.1.5.
 6 A0A061IPV2 A0A061IPV2 E5G6H5 E5G6H5 E5G6H6 E5G6H6