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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291645: Chlorophyll(ide) b reductase NOL, chloroplastic

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Chlorophyll(ide) b reductase. [EC: 1.1.1.294]
7(1)-hydroxychlorophyllide a + NAD(P)(+) = chlorophyllide b + NAD(P)H.
  • Carries out the first step in the conversion of chlorophyll b to chlorophyll a.
  • Involved in chlorophyll degradation, which occurs during leaf senescence and it also forms part of the chlorophyll cycle, which interconverts chlorophyll a and b in response to changing light conditions.
  • While both chlorophyll a and chlorophyll b are found in higher plants, only breakdown products derived from chlorophyll a are found in the end products, i.e. non-fluorescent chlorophyll catabolites (NCCs).
  • The transition from chlorophyll b, which contains a formyl group on C7, to chlorophyll a, which contains a methyl group on C7, proceeds through the intermediate 7(1)-hydroxychlorophyll.
  • Another enzyme, which requires ferredoxin but has not been characterized fully, is required to complete the conversion.
 6 A0A0B2QX29 A0A178UDW6 B8ANJ7 I1MI92 Q84ST4 Q8LEU3
Carbonyl reductase (NADPH). [EC: 1.1.1.184]
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
 1 B9RL30