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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291423: Shikimate dehydrogenase (NADP(+))

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Shikimate dehydrogenase. [EC: 1.1.1.25]
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
  • NAD(+) cannot replace NADP(+).
  • In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
 9344 A0A011A9U8 A0A011A9U8 A0A011QSK9 A0A011QSK9 A0A011V4Q4 A0A011V4Q4 A0A011VH49 A0A011VH49 A0A015KJB4 A0A015KJB4
(9334 more...)
Quinate/shikimate dehydrogenase. [EC: 1.1.1.282]
(1) L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. (2) Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H.
  • This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, in that it can use both quinate and shikimate as substrate and either NAD(+) or NADP(+) as acceptor.
 824 A0A017IIF7 A0A017IIF7 A0A023VB67 A0A023VB67 A0A023YXQ4 A0A023YXQ4 A0A024KWY8 A0A024KWY8 A0A025CQ55 A0A025CQ55
(814 more...)
3,4-dihydroxy-2-butanone-4-phosphate synthase. [EC: 4.1.99.12]
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.
  • The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5.
  • The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.
 34 A0A015S7J1 A0A015S7J1 A0A015TSW5 A0A015TSW5 A0A015V8N9 A0A015V8N9 A0A015WM18 A0A015WM18 A0A016EIU0 A0A016EIU0
(24 more...)
Shikimate kinase. [EC: 2.7.1.71]
ATP + shikimate = ADP + shikimate 3-phosphate.
    		 16 C5ETN2 C5ETN2 D4CG78 D4CG78 D6DDS7 D6DDS7 N9YUK3 N9YUK3 R0C486 R0C486
    (6 more...)
    3-dehydroquinate dehydratase. [EC: 4.2.1.10]
    3-dehydroquinate = 3-dehydroshikimate + H(2)O.
      		 16 A0A0C1HQS2 A0A0C1HQS2 A0A0C1JSI7 A0A0C1JSI7 A0A0J1BAY4 A0A0J1BAY4 A8IZ72 A8IZ72 F2AVW2 F2AVW2
      (6 more...)
      3-phosphoshikimate 1-carboxyvinyltransferase. [EC: 2.5.1.19]
      Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O- (1-carboxyvinyl)-3-phosphoshikimate.
        		 2 A0A0C1JY94 A0A0C1JY94