The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291395: Alpha-aminoadipic semialdehyde synthase, mitochond...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity GO:0047131
Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH.
3 E1BWX4 (/ISS) Q54P64 (/ISS) Q6GN76 (/ISS)
Saccharopine dehydrogenase activity GO:0004753
Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor.
1 F4JVY8 (/IDA)
Saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity GO:0004755
Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH.
1 P38999 (/IDA)
Saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity GO:0004755
Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH.
1 O59711 (/ISO)
Saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity GO:0004755
Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH.
1 Q5B1H9 (/RCA)
Saccharopine dehydrogenase (NADP+, L-lysine-forming) activity GO:0047130
Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH.
1 Q9UDR5 (/EXP)
Saccharopine dehydrogenase (NADP+, L-lysine-forming) activity GO:0047130
Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH.
1 F4JVY8 (/IDA)
Saccharopine dehydrogenase (NADP+, L-lysine-forming) activity GO:0047130
Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH.
1 Q99K67 (/ISO)
Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity GO:0047131
Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH.
1 Q9UDR5 (/EXP)
Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity GO:0047131
Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH.
1 Q99K67 (/IDA)
Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity GO:0047131
Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH.
1 Q99K67 (/ISO)
Saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity GO:0047131
Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH.
1 Q9UDR5 (/NAS)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-lysine catabolic process GO:0019477
The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid.
2 F4JVY8 (/IDA) Q99K67 (/IDA)
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
1 Q99K67 (/TAS)
Lysine metabolic process GO:0006553
The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.
1 Q5B1H9 (/RCA)
Lysine catabolic process GO:0006554
The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.
1 Q54P64 (/ISS)
Lysine catabolic process GO:0006554
The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.
1 Q9UDR5 (/NAS)
Lysine catabolic process GO:0006554
The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.
1 Q9UDR5 (/TAS)
Lysine biosynthetic process GO:0009085
The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.
1 O59711 (/IMP)
L-lysine catabolic process GO:0019477
The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid.
1 F4JVY8 (/IMP)
L-lysine catabolic process GO:0019477
The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid.
1 E1BWX4 (/ISS)
Lysine biosynthetic process via aminoadipic acid GO:0019878
The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.
1 P38999 (/IMP)
Regulation of histone methylation GO:0031060
Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones.
1 Q9VLX0 (/IDA)
Histone arginine methylation GO:0034969
The modification of a histone by addition of a methyl group to an arginine residue.
1 Q9VLX0 (/IDA)
Response to mercury ion GO:0046689
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
1 Q54P64 (/RCA)
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
1 Q9UDR5 (/TAS)
Response to karrikin GO:0080167
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants).
1 F4JVY8 (/IEP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 A4D0W4 (/IDA) Q9UDR5 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q99K67 (/TAS) Q9UDR5 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 F4JVY8 (/IDA) O59711 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 A4D0W4 (/IDA) Q9UDR5 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q54NG9 (/RCA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 F4JVY8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O59711 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q99K67 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q9UDR5 (/TAS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q99K67 (/ISO)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q54P64 (/IDA)