The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291378: Glyoxylate reductase/Glyoxylate reductase/Hydroxyp...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glyoxylate reductase. [EC: 1.1.1.26]
Glycolate + NAD(+) = glyoxylate + NADH.
  • Reduces glyoxylate to glycolate or hydroxypyruvate to D-glycerate.
220 A0A059FMY3 A0A059FMY3 A0A068E575 A0A068E575 A0A069RFQ4 A0A069RFQ4 A0A075LTX8 A0A075LTX8 A0A088E4Z5 A0A088E4Z5
(210 more...)
Phosphoglycerate dehydrogenase. [EC: 1.1.1.95]
3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH.
  • Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis.
  • The reaction occurs predominantly in the direction of reduction.
  • The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399.
144 A0A0B5NVQ6 A0A0B5NVQ6 A0A0E8THX5 A0A0E8THX5 A0A0G4D4T7 A0A0G4D4T7 A0A0G7HLG5 A0A0G7HLG5 A0A0H2HX49 A0A0H2HX49
(134 more...)
Glyoxylate reductase (NADP(+)). [EC: 1.1.1.79]
Glycolate + NADP(+) = glyoxylate + NADPH.
  • Also reduces hydroxypyruvate to glycerate.
  • Has some affinity for NAD(+).
140 A0A068E575 A0A068E575 A0A077U2A8 A0A077U2A8 A0A077VIU6 A0A077VIU6 A0A090N226 A0A090N226 A0A0A8X8D0 A0A0A8X8D0
(130 more...)
4-phosphoerythronate dehydrogenase. [EC: 1.1.1.290]
4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH.
  • This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate.
  • The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+).
  • In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid.
  • Cf. EC 1.1.1.399.
108 A0A069FUP0 A0A069FUP0 A0A090N226 A0A090N226 A0A0E0VRE1 A0A0E0VRE1 A0A0E1AP06 A0A0E1AP06 A0A0E1VI33 A0A0E1VI33
(98 more...)
Hydroxypyruvate reductase. [EC: 1.1.1.81]
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
    98 A0A068E575 A0A068E575 A0A090N226 A0A090N226 A0A0A8X8D0 A0A0A8X8D0 A0A0B5S2L1 A0A0B5S2L1 A0A0E0VRE1 A0A0E0VRE1
    (88 more...)