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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291276: Putative glyoxylate/hydroxypyruvate reductase A

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glyoxylate reductase (NADP(+)). [EC: 1.1.1.79]
Glycolate + NADP(+) = glyoxylate + NADPH.
  • Also reduces hydroxypyruvate to glycerate.
  • Has some affinity for NAD(+).
 1832 A0A014N9W2 A0A014N9W2 A0A017IFI1 A0A017IFI1 A0A022PGL6 A0A022PGL6 A0A023V9R6 A0A023V9R6 A0A023YVK4 A0A023YVK4
(1822 more...)
Hydroxypyruvate reductase. [EC: 1.1.1.81]
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
    		 1652 A0A014N9W2 A0A014N9W2 A0A017IFI1 A0A017IFI1 A0A022PGL6 A0A022PGL6 A0A023V9R6 A0A023V9R6 A0A023YVK4 A0A023YVK4
    (1642 more...)
    Phosphoglycerate dehydrogenase. [EC: 1.1.1.95]
    3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH.
    • Catalyzes the first committed and rate-limiting step in the phosphoserine pathway of serine biosynthesis.
    • The reaction occurs predominantly in the direction of reduction.
    • The enzyme from the bacterium Escherichia coli also catalyzes the activity of EC 1.1.1.399.
    		 148 A0A024KJU0 A0A024KJU0 A0A063Y004 A0A063Y004 A0A068YUK6 A0A068YUK6 A0A069PH95 A0A069PH95 A0A083ZFN3 A0A083ZFN3
    (138 more...)
    4-phosphoerythronate dehydrogenase. [EC: 1.1.1.290]
    4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH.
    • This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate.
    • The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+).
    • In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid.
    • Cf. EC 1.1.1.399.
    		 36 A0A0E2QU28 A0A0E2QU28 B2Q0U8 B2Q0U8 B4ETM6 B4ETM6 B6XI48 B6XI48 C0B2V3 C0B2V3
    (26 more...)
    Glyoxylate reductase. [EC: 1.1.1.26]
    Glycolate + NAD(+) = glyoxylate + NADH.
    • Reduces glyoxylate to glycolate or hydroxypyruvate to D-glycerate.
    		 28 A0A034T5G0 A0A034T5G0 A0A076LPL1 A0A076LPL1 A0A085GBV9 A0A085GBV9 A0A085GU23 A0A085GU23 A0A085U8E4 A0A085U8E4
    (18 more...)
    Gluconate 2-dehydrogenase. [EC: 1.1.1.215]
    D-gluconate + NADP(+) = 2-dehydro-D-gluconate + NADPH.
    • Also acts on L-idonate, D-galactonate and D-xylonate.
    		 26 A0A034T5G0 A0A034T5G0 A0A076LPL1 A0A076LPL1 A0A085GBV9 A0A085GBV9 A0A085GU23 A0A085GU23 A0A085U8E4 A0A085U8E4
    (16 more...)