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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291226: Zinc-binding dehydrogenase family oxidoreductase

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NADPH:quinone reductase. [EC: 1.6.5.5]
NADPH + 2 quinone = NADP(+) + 2 semiquinone.
  • Specific for NADPH.
  • Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates.
  • Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive inhibitors with respect to the quinone substrate.
  • The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O(2).
  • Abundant in the lens of the eye of some mammalian species.
 222 A0A009R5Q8 A0A009R5Q8 A0A031GZ70 A0A031GZ70 A0A062DCX8 A0A062DCX8 A0A062EZB9 A0A062EZB9 A0A068YR93 A0A068YR93
(212 more...)
2-alkenal reductase (NAD(P)(+)). [EC: 1.3.1.74]
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
  • Highly specific for 4-hydroxynon-2-enal and non-2-enal.
  • Alk-2-enals of shorter chain have lower affinities.
  • Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one.
  • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
  • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
 200 A0A031I755 A0A031I755 A0A059MPA5 A0A059MPA5 A0A059MV32 A0A059MV32 A0A063BDC9 A0A063BDC9 A0A063BM74 A0A063BM74
(190 more...)
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 102 A0A089QBS7 A0A089QBS7 A0A0E1AKN8 A0A0E1AKN8 A0A0H2VHL1 A0A0H2VHL1 A0A0H2WZ89 A0A0H2WZ89 A0A0H2XIR0 A0A0H2XIR0
(92 more...)
15-oxoprostaglandin 13-reductase. [EC: 1.3.1.48]
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
  • Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives.
  • The enzyme from placenta is specific for NAD(+).
 52 A0A061IFW0 A0A061IFW0 A0A061IIF3 A0A061IIF3 A0A061IJG8 A0A061IJG8 A0A061ILI0 A0A061ILI0 A0A0A0G349 A0A0A0G349
(42 more...)
Curcumin reductase. [EC: 1.3.1.n3]
Tetrahydrocurcumin + 2 NADP(+) = curcumin + 2 NADPH.
  • The enzyme, from the bacterium Escherichia coli is also active with 3-octene-2-one (59.7%), 3-hepten-2-one (28%), and resveratrol (14.8%).
 36 A0A037YEC2 A0A037YEC2 A0A069XFY2 A0A069XFY2 A0A070UZ02 A0A070UZ02 A0A074IJU9 A0A074IJU9 A0A0E1LWX3 A0A0E1LWX3
(26 more...)
Delta(4)-3-oxosteroid 5-beta-reductase. [EC: 1.3.1.3]
(1) 5-beta-cholestan-3-one + NADP(+) = cholest-4-en-3-one + NADPH. (2) 17,21-dihydroxy-5-beta-pregnane-3,11,20-trione + NADP(+) = cortisone + NADPH.
  • The enzyme from human efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent.
  • The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3- one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
 4 S0AJ59 S0AJ59 S4YK04 S4YK04
Acrylyl-CoA reductase (NADPH). [EC: 1.3.1.84]
Propanoyl-CoA + NADP(+) = acrylyl-CoA + NADPH.
  • Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
  • The reaction is catalyzed in the opposite direction to that shown.
  • The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA.
  • Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16.
 2 A0A0P7H8N3 A0A0P7H8N3
IMP dehydrogenase. [EC: 1.1.1.205]
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
  • The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
  • Formerly EC 1.2.1.14.
 2 U2WAG7 U2WAG7
4-hydroxy-tetrahydrodipicolinate reductase. [EC: 1.17.1.8]
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)(+) + H(2)O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.
  • Studies of the enzyme from the bacterium Escherichia coli have shown that the enzyme accepts (2S,4S)-4-hydroxy-2,3,4,5- tetrahydrodipicolinate and not (S)-2,3-dihydrodipicolinate as originally thought.
  • Formerly EC 1.3.1.26.
 2 U2WAD5 U2WAD5
Histidine kinase. [EC: 2.7.13.3]
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
  • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
  • A number of histones can act as acceptor.
 2 U2WSL0 U2WSL0
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