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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291191: Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

There are 23 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase. [EC: 1.3.1.87]
(1) 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+) = 3-(2,3-dihydroxyphenyl)propanoate + NADH. (2) (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH.
  • This enzyme catalyzes a step in the pathway of phenylpropanoid compounds degradation.
  • Formerly EC 1.3.1.n1.
 492 A0A009FPE8 A0A009FPE8 A0A009K792 A0A009K792 A0A024KZL1 A0A024KZL1 A0A024KZQ3 A0A024KZQ3 A0A026RXX6 A0A026RXX6
(482 more...)
2-deoxy-D-gluconate 3-dehydrogenase. [EC: 1.1.1.125]
2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + NADH.
    		 420 A0A017H563 A0A017H563 A0A023PAM9 A0A023PAM9 A0A024KQH6 A0A024KQH6 A0A026V978 A0A026V978 A0A029KH10 A0A029KH10
    (410 more...)
    3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
    (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
    • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
    		 288 A0A024KCE6 A0A024KCE6 A0A069QC10 A0A069QC10 A0A080UFG7 A0A080UFG7 A0A081LEV3 A0A081LEV3 A0A084GS42 A0A084GS42
    (278 more...)
    2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase. [EC: 1.1.1.127]
    2-dehydro-3-deoxy-D-gluconate + NAD(+) = (4S)-4,6-dihydroxy-2,5- dioxohexanoate + NADH.
    • The enzyme from Pseudomonas acts equally well on NAD(+) or NADP(+), while those from Erwinia chrysanthemi and Escherichia coli are more specific for NAD(+).
    		 260 A0A024KQH6 A0A024KQH6 A0A026V978 A0A026V978 A0A028A6Q0 A0A028A6Q0 A0A028ECJ7 A0A028ECJ7 A0A029KH10 A0A029KH10
    (250 more...)
    Gluconate 5-dehydrogenase. [EC: 1.1.1.69]
    D-gluconate + NAD(P)(+) = 5-dehydro-D-gluconate + NAD(P)H.
      		 164 A0A024KQH6 A0A024KQH6 A0A026V978 A0A026V978 A0A029KH10 A0A029KH10 A0A037YBB0 A0A037YBB0 A0A070CIJ0 A0A070CIJ0
      (154 more...)
      Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase. [EC: 1.3.1.56]
      Cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + NADH.
      • Catalyzes the second step in the biphenyl degradation pathway in bacteria.
      		 114 A0A063BBE0 A0A063BBE0 A0A063BD86 A0A063BD86 A0A081RAE8 A0A081RAE8 A0A097SRI2 A0A097SRI2 A0A0A1FPI7 A0A0A1FPI7
      (104 more...)
      Glucose 1-dehydrogenase (NAD(P)(+)). [EC: 1.1.1.47]
      D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H.
      • This enzyme has similar activity with either NAD(+) or NADP(+).
      • Cf. EC 1.1.1.118 and EC 1.1.1.119.
      		 104 A0A045IKR6 A0A045IKR6 A0A083VSS0 A0A083VSS0 A0A0D0SX24 A0A0D0SX24 A0A0D6HYR1 A0A0D6HYR1 A0A0D6J172 A0A0D6J172
      (94 more...)
      Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase. [EC: 1.3.1.19]
      Cis-1,2-dihydrobenzene-1,2-diol + NAD(+) = catechol + NADH.
        		 16 A0A0K2Y9S3 A0A0K2Y9S3 D5PIB0 D5PIB0 E6TIQ4 E6TIQ4 I7CDY7 I7CDY7 P08088 P08088
        (6 more...)
        Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase. [EC: 1.3.1.29]
        (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) = naphthalene-1,2-diol + NADH.
        • Also acts, at half the rate, on cis-anthracene dihydrodiol and cis- phenanthrene dihydrodiol.
        		 8 A0A0M3ALJ8 A0A0M3ALJ8 A0A197BUW1 A0A197BUW1 Q14RW3 Q14RW3 U5XNU4 U5XNU4
        Pteridine reductase. [EC: 1.5.1.33]
        5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 NADPH.
        • The enzyme from Leishmania (both amastigote and promastigote forms) catalyzes the NADPH-dependent reduction of folate and a wide variety of unconjugated pterins, including biopterin, to their tetrahydro forms.
        • It also catalyzes the reduction of 7,8-dihydropterins and 7,8- dihydrofolate to their tetrahydro forms.
        • In contrast to EC 1.5.1.3 and EC 1.5.1.34, pteridine reductase will not catalyze the reduction of the quinonoid form of dihydrobiopterin.
        • The enzyme is specific for NADPH; no activity has been detected with NADH.
        • It also differs from EC 1.5.1.3 in being specific for the B side of NADPH.
        • Formerly EC 1.1.1.253.
        		 4 A0A1L5QHU7 A0A1L5QHU7 Q3BXN4 Q3BXN4
        Aldose 1-dehydrogenase (NAD(+)). [EC: 1.1.1.121]
        D-aldose + NAD(+) = D-aldonolactone + NADH.
        • Acts on D-glucose, 2-deoxy- and 6-deoxy-D-glucose, D-galactose, 6-deoxy-D-galactose, 2-deoxy-L-arabinose and D-xylose.
        		 4 A0A1A7UFL1 A0A1A7UFL1 R2RFA5 R2RFA5
        Cyclopentanol dehydrogenase. [EC: 1.1.1.163]
        Cyclopentanol + NAD(+) = cyclopentanone + NADH.
        • 4-methylcyclohexanol and cyclohexanol can also act as substrates.
        		 4 A0A0E1JB92 A0A0E1JB92 A0A155X228 A0A155X228
        2,6-dioxo-6-phenylhexa-3-enoate hydrolase. [EC: 3.7.1.8]
        2,6-dioxo-6-phenylhexa-3-enoate + H(2)O = benzoate + 2-oxopent-4-enoate.
        • Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 by ring-fission at a -CO-C bond.
        • Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.
        		 2 F8GQY4 F8GQY4
        Branched-chain-amino-acid transaminase. [EC: 2.6.1.42]
        (1) L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate. (2) L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate. (3) L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.
        • Also acts on L-isoleucine and L-valine.
        • Different from EC 2.6.1.66.
        		 2 A0A061I189 A0A061I189
        Acetoacetyl-CoA reductase. [EC: 1.1.1.36]
        (R)-3-hydroxyacyl-CoA + NADP(+) = 3-oxoacyl-CoA + NADPH.
          		 2 D2Q5R4 D2Q5R4
          Diacetyl reductase ((S)-acetoin forming). [EC: 1.1.1.304]
          (S)-acetoin + NAD(+) = diacetyl + NADH.
          • The reaction is catalyzed in the reverse direction.
          • This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76).
          • While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible.
          • This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae.
          • Different from EC 1.1.1.303.
          • Formerly EC 1.1.1.5.
          		 2 A0A0B8N7L9 A0A0B8N7L9
          Carbonyl reductase (NADPH). [EC: 1.1.1.184]
          R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
          • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
          • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
          		 2 U4Q233 U4Q233
          17-beta-estradiol 17-dehydrogenase. [EC: 1.1.1.62]
          17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
          • The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.
          • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
          • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
          		 2 G7LKB3 G7LKB3
          3-alpha(or 20-beta)-hydroxysteroid dehydrogenase. [EC: 1.1.1.53]
          Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
          • The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.
          		 2 U2XPZ8 U2XPZ8
          DNA-directed RNA polymerase. [EC: 2.7.7.6]
          Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
          • Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
          • Can initiate a chain de novo.
          • In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized.
          • See also EC 2.7.7.19 and EC 2.7.7.48.
          		 2 H8IKX3 H8IKX3
          (S,S)-butanediol dehydrogenase. [EC: 1.1.1.76]
          (2S,3S)-butane-2,3-diol + NAD(+) = (S)-acetoin + NADH.
          • This enzyme catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol.
          • It can also catalyze the irreversible reduction of diacetyl to (S)- acetoin.
          		 2 A0A0B8N7L9 A0A0B8N7L9
          3-hydroxybutyrate dehydrogenase. [EC: 1.1.1.30]
          (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.
          • Also oxidizes other 3-hydroxymonocarboxylic acids.
          		 2 A0A173L0K3 A0A173L0K3
          Cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase. [EC: 1.3.1.49]
          (+)-cis-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = phenanthrene-3,4-diol + NADH.
            		 2 Q9WXG7 Q9WXG7