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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 291033: Bifunctional glyoxylate/hydroxypyruvate reductase ...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glyoxylate reductase (NADP(+)). [EC: 1.1.1.79]
Glycolate + NADP(+) = glyoxylate + NADPH.
  • Also reduces hydroxypyruvate to glycerate.
  • Has some affinity for NAD(+).
 1334 A0A014N9W2 A0A014N9W2 A0A017IFI1 A0A017IFI1 A0A022PGL6 A0A022PGL6 A0A023V9R6 A0A023V9R6 A0A023YVK4 A0A023YVK4
(1324 more...)
Hydroxypyruvate reductase. [EC: 1.1.1.81]
D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.
    		 1318 A0A014N9W2 A0A014N9W2 A0A017IFI1 A0A017IFI1 A0A022PGL6 A0A022PGL6 A0A023V9R6 A0A023V9R6 A0A023YVK4 A0A023YVK4
    (1308 more...)
    4-phosphoerythronate dehydrogenase. [EC: 1.1.1.290]
    4-phospho-D-erythronate + NAD(+) = (3R)-3-hydroxy-2-oxo-4- phosphonooxybutanoate + NADH.
    • This enzyme catalyzes a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate.
    • The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD(+).
    • In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyzes the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)- hydroxy acid.
    • Cf. EC 1.1.1.399.
    		 16 A0A0E2QU28 A0A0E2QU28 B4ETM6 B4ETM6 B6XI48 B6XI48 C2LFL9 C2LFL9 D4BUD1 D4BUD1
    (6 more...)
    Gluconate 2-dehydrogenase. [EC: 1.1.1.215]
    D-gluconate + NADP(+) = 2-dehydro-D-gluconate + NADPH.
    • Also acts on L-idonate, D-galactonate and D-xylonate.
    		 10 A0A034T5G0 A0A034T5G0 A0A076LPL1 A0A076LPL1 A0A085U8E4 A0A085U8E4 A0A0H3DSG9 A0A0H3DSG9 D0ZGY1 D0ZGY1
    Glyoxylate reductase. [EC: 1.1.1.26]
    Glycolate + NAD(+) = glyoxylate + NADH.
    • Reduces glyoxylate to glycolate or hydroxypyruvate to D-glycerate.
    		 10 A0A034T5G0 A0A034T5G0 A0A076LPL1 A0A076LPL1 A0A085U8E4 A0A085U8E4 A0A0H3DSG9 A0A0H3DSG9 D0ZGY1 D0ZGY1