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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 290531: Acetaldehyde dehydrogenase 4

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acetaldehyde dehydrogenase (acetylating). [EC: 1.2.1.10]
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH.
  • Also acts, more slowly, on glycolaldehyde, propanal and butanal.
  • In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39.
  • The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87.
  • Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols.
  • NADP(+) can replace NAD(+) but the rate of reaction is much slower.
 5522 A0A009E9M7 A0A009E9M7 A0A009JR67 A0A009JR67 A0A010RLT8 A0A010RLT8 A0A010RX34 A0A010RX34 A0A010SZX2 A0A010SZX2
(5512 more...)
Propanal dehydrogenase (CoA-propanoylating). [EC: 1.2.1.87]
Propanal + CoA + NAD(+) = propanoyl-CoA + NADH.
  • The enzyme forms a bifunctional complex with EC 4.1.3.43, with a tight channel connecting the two subunits.
  • Also acts, more slowly, on glycolaldehyde and butanal.
  • In Pseudomonas species the enzyme forms a bifunctional complex with EC 4.1.3.39.
  • The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.10.
  • NADP(+) can replace NAD(+) with a much slower rate.
 20 A0A160J1B9 A0A160J1B9 A0A1J5PFK0 A0A1J5PFK0 A0A1J5RQA4 A0A1J5RQA4 A0A1L7FXI1 A0A1L7FXI1 B3VTK4 B3VTK4
(10 more...)