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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 289729: NADH-ubiquinone oxidoreductase 40 kDa subunit, mit...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NADH:ubiquinone reductase (H(+)-translocating). [EC: 1.6.5.3]
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
  • The complex is present in mitochondria and aerobic bacteria.
  • Breakdown of the complex can release EC 1.6.99.3.
  • In photosynthetic bacteria, reversed electron transport through this enzyme can reduce NAD(+) to NADH.
 17 A0A0B2SVI5 A0A0C1MWM0 A0A0J5Q705 A0A0J6F3Q2 A0A1G4KQH0 A2QSH0 A3LP06 B0Y8W5 B9WDD0 C4R4G2
(7 more...)
NADH dehydrogenase. [EC: 1.6.99.3]
NADH + acceptor = NAD(+) + reduced acceptor.
  • After preparations have been subjected to certain treatments cytochrome c may act as acceptor.
  • Under normal conditions, two protons are extruded from the cytoplasm or the intramitochondrial or stromal compartment.
  • Present in a mitochondrial complex as EC 1.6.5.3.
  • Formerly EC 1.6.2.1.
 6 A0A0C1MWM0 B0T670 B8MAP5 B9SKL5 F4QVR8 Q9VPE2
DTDP-4-dehydrorhamnose reductase. [EC: 1.1.1.133]
dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + NADPH.
  • In the reverse direction, reduction on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyzes epimerization at C-3 and C-5; the complex has been referred to as dTDP-L-rhamnose synthase.
 2 A0A165QSK6 A0A165W4S7