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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 289525: Enoyl-[acyl-carrier-protein] reductase [NADPH] Fab...

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific). [EC: 1.3.1.10]
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
  • One of the activities of EC 2.3.1.86, an enzyme found in yeasts (Ascomycota and the Basidiomycota).
  • Catalyzes the reduction of enoyl-acyl-[acyl-carrier protein] derivatives of carbon chain length from 4 to 16.
  • The yeast enzyme is Si-specific with respect to NADP(+).
  • Cf. EC 1.3.1.39 and EC 1.3.1.104 which describes enzymes whose stereo-specificity toward NADPH is not known.
  • See also EC 1.3.1.9.
 190 A0A063XIG1 A0A063XIG1 A0A063Z1A9 A0A063Z1A9 A0A080UHU6 A0A080UHU6 A0A081L972 A0A081L972 A0A084GJJ7 A0A084GJJ7
(180 more...)
Enoyl-[acyl-carrier-protein] reductase. [EC: 1.3.1.104]
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
  • The enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to the acyl- carrier protein, in an NADPH-dependent manner.
  • This entry stands for enzymes whose stereo-specificity with respect to NADP(+) is not known (cf. EC 1.3.1.39, EC 1.3.1.10 and EC 1.3.1.9).
 66 A0A063XIG1 A0A063XIG1 A0A063Z1A9 A0A063Z1A9 A0A081L972 A0A081L972 A0A0B4S5L1 A0A0B4S5L1 A0A0D7XR75 A0A0D7XR75
(56 more...)
Enoyl-[acyl-carrier-protein] reductase (NADH). [EC: 1.3.1.9]
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADH.
  • The enzyme catalyzes an essential step in fatty acid biosynthesis, the reduction of the 2,3-double bond in enoyl-acyl-[acyl-carrier- protein] derivatives of the elongating fatty acid moiety.
  • The enzyme from the bacterium Escherichia coli accepts substrates with carbon chain length from 4 to 18.
  • The enzyme from the bacterium Mycobacterium tuberculosis prefers substrates with carbon chain length from 12 to 24 carbons.
 38 A0A0A0TLU6 A0A0A0TLU6 A0A0D7XR75 A0A0D7XR75 A0A0E1LMG5 A0A0E1LMG5 A0A0Q6H6J8 A0A0Q6H6J8 A0A0T6LI15 A0A0T6LI15
(28 more...)
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
  • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
 28 A0A0A0TLU6 A0A0A0TLU6 A0A0M0KPB4 A0A0M0KPB4 A0A0Q6H6J8 A0A0Q6H6J8 A0A0T6LI15 A0A0T6LI15 A0A0X9PXJ6 A0A0X9PXJ6
(18 more...)
Alcohol dehydrogenase. [EC: 1.1.1.1]
(1) An alcohol + NAD(+) = an aldehyde or ketone + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
  • Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol.
  • The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.
 14 A0A0L1MAN4 A0A0L1MAN4 A0A0M0WA21 A0A0M0WA21 A0A0Q6I0T4 A0A0Q6I0T4 A0A0Q9U7N7 A0A0Q9U7N7 A0A109G6N6 A0A109G6N6
(4 more...)
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