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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 289239: Retinol dehydrogenase type 1

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
All-trans-retinol dehydrogenase (NAD(+)). [EC: 1.1.1.105]
All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) = all- trans-retinal-[cellular-retinol-binding-protein] + NADH.
  • The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD(+)/NADH as cofactors.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form.
  • No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315).
  • Also active with 3-alpha-hydroxysteroids.
 22 A0A024RB43 A0A061INA4 A0A0S4LRY2 B2J3L0 B7PYT5 B7Q686 B7QBC9 D8FX32 E0VWY3 F8B3V1
(12 more...)
Diacetyl reductase ((S)-acetoin forming). [EC: 1.1.1.304]
(S)-acetoin + NAD(+) = diacetyl + NADH.
  • The reaction is catalyzed in the reverse direction.
  • This activity is usually associated with butanediol dehydrogenase activity (EC 1.1.1.4 or EC 1.1.1.76).
  • While the butanediol dehydrogenase activity is reversible, diacetyl reductase activity is irreversible.
  • This enzyme has been reported in the bacteria Geobacillus stearothermophilus, Enterobacter aerogenes and Klebsiella pneumoniae.
  • Different from EC 1.1.1.303.
  • Formerly EC 1.1.1.5.
 12 A0A069Q716 A0A0D0TKL3 A0A0E1AQ26 A0A0H2ZCS4 A0A0P1D8N7 A0A157WB91 A0A1D5BZ70 A0A1E9CUR1 A0A1F0IJE7 A0A1G5F1I3
(2 more...)
17-beta-estradiol 17-dehydrogenase. [EC: 1.1.1.62]
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
  • The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
  • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
 9 A0A024RB43 A0A061I758 O14756 O54753 P37059 P51658 Q3T001 Q62730 Q9R092
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)). [EC: 1.1.1.239]
Testosterone + NAD(+) = androstenedione + NADH.
  • Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids.
  • Different from EC 1.1.1.50 or EC 1.1.1.213.
  • Formerly EC 1.1.1.63.
 8 A0A024RB43 O14756 O54753 P37059 P51658 Q3T001 Q62730 Q9R092
3-hydroxybutyrate dehydrogenase. [EC: 1.1.1.30]
(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH.
  • Also oxidizes other 3-hydroxymonocarboxylic acids.
 7 K8YYM1 P29147 Q02337 Q02338 Q5ZJZ5 Q80XN0 Q9VAH3
11-cis-retinol dehydrogenase. [EC: 1.1.1.315]
11-cis-retinol-[retinal-binding-protein] + NAD(+) = 11-cis-retinal- [retinol-binding-protein] + NADH.
  • This enzyme, abundant in the retinal pigment epithelium, catalyzes the reduction of 11-cis-retinol to 11-cis-retinal while the substrate is bound to the retinal-binding protein.
  • This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin.
  • The enzyme can also accept other cis forms of retinol.
 4 A0A024RB18 O55240 Q27979 Q92781
11-beta-hydroxysteroid dehydrogenase. [EC: 1.1.1.146]
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.
    		 2 A0A061I708 A0A191Y1Z6