The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 287896: Fatty acyl-CoA reductase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fatty-acyl-CoA reductase (alcohol-forming) activity GO:0080019
Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.
26 A1ZAI3 (/ISS) A1ZAI5 (/ISS) A8JNC9 (/ISS) Q0E8W1 (/ISS) Q0P5J1 (/ISS) Q5BI89 (/ISS) Q5R834 (/ISS) Q5ZM72 (/ISS) Q66H50 (/ISS) Q7K3T3 (/ISS)
(16 more)
Fatty-acyl-CoA reductase (alcohol-forming) activity GO:0080019
Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.
10 B9TSP7 (/IDA) D2SNU9 (/IDA) I7LW01 (/IDA) Q08891 (/IDA) Q1PEI6 (/IDA) Q39152 (/IDA) Q8S7T9 (/IDA) Q8WVX9 (/IDA) Q93ZB9 (/IDA) Q96K12 (/IDA)
Long-chain-fatty-acyl-CoA reductase activity GO:0050062
Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.
6 Q0WRB0 (/IDA) Q39152 (/IDA) Q7TNT2 (/IDA) Q8MS59 (/IDA) Q922J9 (/IDA) Q9LXN3 (/IDA)
Long-chain-fatty-acyl-CoA reductase activity GO:0050062
Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.
3 A1ZAI3 (/ISS) A1ZAI5 (/ISS) Q960W6 (/ISS)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
2 Q8WVX9 (/TAS) Q96K12 (/TAS)
Fatty-acyl-CoA reductase (alcohol-forming) activity GO:0080019
Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.
2 Q7TNT2 (/ISO) Q922J9 (/ISO)
Glycerone-phosphate O-acyltransferase activity GO:0016287
Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA.
1 I7LW01 (/IDA)
Oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628
Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.
1 Q08891 (/ISS)
Fatty-acyl-CoA reductase (alcohol-forming) activity GO:0080019
Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA.
1 Q93ZB9 (/IMP)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Wax biosynthetic process GO:0010025
The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids.
8 A1ZAI3 (/ISS) A1ZAI5 (/ISS) Q5R834 (/ISS) Q5ZM72 (/ISS) Q66H50 (/ISS) Q7ZXF5 (/ISS) Q8WVX9 (/ISS) Q960W6 (/ISS)
Ether lipid biosynthetic process GO:0008611
The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
6 A1ZAI5 (/ISS) Q5R834 (/ISS) Q5ZM72 (/ISS) Q66H50 (/ISS) Q7ZXF5 (/ISS) Q922J9 (/ISS)
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
4 Q0E8W1 (/IMP) Q5BI89 (/IMP) Q8MMC6 (/IMP) Q9W0Y5 (/IMP)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
4 Q0E8W1 (/IMP) Q5BI89 (/IMP) Q8MMC6 (/IMP) Q9W0Y5 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
3 Q0WRB0 (/IEP) Q39152 (/IEP) Q9LXN3 (/IEP)
Wax biosynthetic process GO:0010025
The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids.
3 Q7TNT2 (/TAS) Q8WVX9 (/TAS) Q96K12 (/TAS)
Suberin biosynthetic process GO:0010345
The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols.
3 Q0WRB0 (/IMP) Q39152 (/IMP) Q9LXN3 (/IMP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
2 B9TSP7 (/IEP) Q0WRB0 (/IEP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
2 Q39152 (/IMP) Q9LXN3 (/IMP)
Pollen exine formation GO:0010584
The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine.
2 Q08891 (/IMP) Q8S7T9 (/IMP)
Long-chain fatty-acyl-CoA metabolic process GO:0035336
The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
2 Q8WVX9 (/IDA) Q96K12 (/IDA)
Long-chain fatty-acyl-CoA metabolic process GO:0035336
The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
2 Q7TNT2 (/ISO) Q922J9 (/ISO)
Ether lipid biosynthetic process GO:0008611
The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
1 Q8WVX9 (/IDA)
Ether lipid biosynthetic process GO:0008611
The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
1 Q8WVX9 (/IMP)
Ether lipid biosynthetic process GO:0008611
The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.
1 Q922J9 (/ISO)
Wax biosynthetic process GO:0010025
The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids.
1 Q922J9 (/IDA)
Wax biosynthetic process GO:0010025
The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids.
1 Q93ZB9 (/IMP)
Liquid clearance, open tracheal system GO:0035002
The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system.
1 Q8MS59 (/IMP)
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
1 Q8MS59 (/IMP)
Glycerophospholipid biosynthetic process GO:0046474
The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
1 Q8WVX9 (/IDA)
Glycerophospholipid biosynthetic process GO:0046474
The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
1 Q922J9 (/ISO)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q8MS59 (/IDA)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of peroxisomal membrane GO:0005779
The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
9 A1ZAI3 (/ISS) A1ZAI5 (/ISS) Q0P5J1 (/ISS) Q5R834 (/ISS) Q5ZM72 (/ISS) Q66H50 (/ISS) Q7TNT2 (/ISS) Q7ZXF5 (/ISS) Q922J9 (/ISS)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
4 E9PNW8 (/IDA) Q7TNT2 (/IDA) Q8WVX9 (/IDA) Q922J9 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
4 A1ZAI3 (/ISS) A1ZAI5 (/ISS) Q960W6 (/ISS) Q96K12 (/ISS)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 B9TSP7 (/IDA) Q39152 (/IDA) Q8S7T9 (/IDA)
Integral component of peroxisomal membrane GO:0005779
The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q8WVX9 (/IDA) Q96K12 (/IDA)
Peroxisomal matrix GO:0005782
The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase.
2 Q8WVX9 (/TAS) Q96K12 (/TAS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 D2SNU9 (/IDA) Q93ZB9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8MS59 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q57TU9 (/RCA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
1 Q922J9 (/ISO)
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
1 Q8WVX9 (/IDA)
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
1 A1ZAI5 (/ISM)
Peroxisomal membrane GO:0005778
The lipid bilayer surrounding a peroxisome.
1 Q922J9 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q39152 (/IDA)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
1 Q960W6 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q8MS59 (/IDA)