The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 286645: Glyceraldehyde-3-phosphate dehydrogenase B, chloro...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating). [EC: 1.2.1.13]
D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = 3-phospho-D- glyceroyl phosphate + NADPH.
    34 A0A178VLF6 A0A178VLF6 A0A178WA64 A0A178WA64 A8HP84 A8HP84 P09043 P09043 P09044 P09044
    (24 more...)
    Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). [EC: 1.2.1.12]
    D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
    • Also acts very slowly on D-glyceraldehyde and some other aldehydes.
    • Thiols can replace phosphate.
    4 P80505 P80505 Q20FC5 Q20FC5
    Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating). [EC: 1.2.1.59]
    D-glyceraldehyde 3-phosphate + phosphate + NAD(P)(+) = 3-phospho-D- glyceroyl phosphate + NAD(P)H.
    • NAD(+) and NADP(+) can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 and EC 1.2.1.13, which are NAD(+)- and NADP(+)- dependent, respectively.
    2 P80505 P80505