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CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 286605: 3-hydroxyacyl-CoA dehydrogenase type-2 isoform 1

There are 13 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-hydroxyacyl-CoA dehydrogenase. [EC: 1.1.1.35]
(S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
  • Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.
  • Some enzymes act, more slowly, with NADP(+).
  • Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
 198 A0A024HHV8 A0A024HHV8 A0A061HXL9 A0A061HXL9 A0A073A1E2 A0A073A1E2 A0A076EMW9 A0A076EMW9 A0A077JVP3 A0A077JVP3
(188 more...)
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
  • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
 94 A0A010SJL5 A0A010SJL5 A0A011MGD1 A0A011MGD1 A0A045J2W3 A0A045J2W3 A0A080MAE0 A0A080MAE0 A0A083WEB9 A0A083WEB9
(84 more...)
3-hydroxy-2-methylbutyryl-CoA dehydrogenase. [EC: 1.1.1.178]
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methylacetoacetyl-CoA + NADH.
  • Also acts, more slowly, on (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
 62 A0A059MGR5 A0A059MGR5 A0A099KEG2 A0A099KEG2 A0A0C2W936 A0A0C2W936 A0A0K1J892 A0A0K1J892 A0A0S2Z410 A0A0S2Z410
(52 more...)
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase. [EC: 1.1.1.53]
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH.
  • The 3-alpha-hydroxy group or 20-beta-hydroxy group of pregnane and androstane steroids can act as donor.
 38 A0A011PTB8 A0A011PTB8 A0A011PVX4 A0A011PVX4 A0A077JVP3 A0A077JVP3 A0A080LSU5 A0A080LSU5 A0A0B8NID2 A0A0B8NID2
(28 more...)
3(or 17)-beta-hydroxysteroid dehydrogenase. [EC: 1.1.1.51]
Testosterone + NAD(P)(+) = androst-4-ene-3,17-dione + NAD(P)H.
  • Also acts on other 3-beta- or 17-beta-hydroxysteroids (cf. EC 1.1.1.209).
 16 A0A0S2Z410 A0A0S2Z410 A0A1A8XIX2 A0A1A8XIX2 H2QYN3 H2QYN3 O02691 O02691 O08756 O08756
(6 more...)
4-formylbenzenesulfonate dehydrogenase. [EC: 1.2.1.62]
4-formylbenzenesulfonate + NAD(+) + H(2)O = 4-sulfobenzoate + NADH.
  • Involved in the toluene-4-sulfonate degradation pathway.
 4 A0A119A4Y4 A0A119A4Y4 A0A127MT21 A0A127MT21
7-alpha-hydroxysteroid dehydrogenase. [EC: 1.1.1.159]
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD(+) = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH.
  • Catalyzes the oxidation of the 7-alpha-hydroxy group of bile acids and alcohols both in their free and conjugated forms.
  • The Bacteroides fragilis and Clostridium enzymes can also utilize NADP(+).
 2 E3TDR7 E3TDR7
L-lactate dehydrogenase. [EC: 1.1.1.27]
(S)-lactate + NAD(+) = pyruvate + NADH.
  • Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
  • NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
 2 A0A0N0RFK1 A0A0N0RFK1
Transferred entry: 1.1.1.239. [EC: 1.1.1.63]
    		2 E3TDR7 E3TDR7
    17-beta-estradiol 17-dehydrogenase. [EC: 1.1.1.62]
    17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
    • The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids.
    • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
    • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
    		 2 E3TDR7 E3TDR7
    3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)). [EC: 1.1.1.239]
    Testosterone + NAD(+) = androstenedione + NADH.
    • Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids.
    • Different from EC 1.1.1.50 or EC 1.1.1.213.
    • Formerly EC 1.1.1.63.
    		 2 E3TDR7 E3TDR7
    Acetoacetyl-CoA reductase. [EC: 1.1.1.36]
    (R)-3-hydroxyacyl-CoA + NADP(+) = 3-oxoacyl-CoA + NADPH.
      		 2 E3TDR7 E3TDR7
      7-beta-hydroxysteroid dehydrogenase (NADP(+)). [EC: 1.1.1.201]
      A 7-beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + NADPH.
      • Catalyzes the oxidation of the 7-beta-hydroxy group of bile acids such as ursodeoxycholate.
      		 2 E3TDR7 E3TDR7