View in Gene3D

CATH Superfamily 3.40.50.720

NAD(P)-binding Rossmann-like Domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 286571: Dehydrogenase/reductase SDR family member 4

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Carbonyl reductase (NADPH). [EC: 1.1.1.184]
R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.
  • Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin, and prostaglandins E and F, reducing them to the corresponding alcohol.
  • Si-specific with respect to NADPH (cf. EC 1.1.1.2).
 28 A0A0D2MFA9 A0A0D2MFA9 B6ATZ4 B6ATZ4 B7RQX0 B7RQX0 B9RXD8 B9RXD8 E0V9E6 E0V9E6
(18 more...)
3-oxoacyl-[acyl-carrier-protein] reductase. [EC: 1.1.1.100]
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
  • Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.
 16 A0A0P1J507 A0A0P1J507 A0A0P1J922 A0A0P1J922 A0A109CBA3 A0A109CBA3 A0A154C4W4 A0A154C4W4 A0A1E1VAI5 A0A1E1VAI5
(6 more...)
Protein-serine/threonine phosphatase. [EC: 3.1.3.16]
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
  • A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48).
  • The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).
 2 A0A0N4YEX9 A0A0N4YEX9
Glucose 1-dehydrogenase (NAD(P)(+)). [EC: 1.1.1.47]
D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H.
  • This enzyme has similar activity with either NAD(+) or NADP(+).
  • Cf. EC 1.1.1.118 and EC 1.1.1.119.
 2 K1M212 K1M212