The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NAD(P)-binding Rossmann-like Domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 286273: SUMO-activating enzyme subunit 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 22 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
9 Q28GH3 (/ISS) Q54L40 (/ISS) Q642Q1 (/ISS) Q7KUA4 (/ISS) Q7SXG4 (/ISS) Q7ZY60 (/ISS) Q9SJT1 (/ISS) Q9VSD9 (/ISS) Q9Z1F9 (/ISS)
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
4 Q9NAN1 (/IDA) Q9SJT1 (/IDA) Q9UBT2 (/IDA) Q9Z1F9 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q9SJT1 (/IPI) Q9UBT2 (/IPI) Q9Z1F9 (/IPI)
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
2 O42939 (/ISO) Q9Z1F9 (/ISO)
Ubiquitin activating enzyme binding GO:0033134
Interacting selectively and non-covalently with a ubiquitin activating enzyme, any of the E1 proteins.
2 Q7KUA4 (/IPI) Q9VSD9 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q9UBT2 (/IMP)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q9Z1F9 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9UBT2 (/IMP)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9Z1F9 (/ISO)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
1 Q9UBT2 (/TAS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.
1 Q9Z1F9 (/IPI)
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
1 Q5BAI0 (/IMP)
SUMO activating enzyme activity GO:0019948
Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
1 Q9UBT2 (/TAS)
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
1 Q9UBT2 (/IPI)
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
1 Q9Z1F9 (/ISO)
Small protein activating enzyme binding GO:0044388
Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme.
1 Q9UBT2 (/IPI)
Small protein activating enzyme binding GO:0044388
Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme.
1 Q9Z1F9 (/ISO)
Ubiquitin-like protein conjugating enzyme binding GO:0044390
Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme.
1 Q9UBT2 (/IPI)
Ubiquitin-like protein conjugating enzyme binding GO:0044390
Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme.
1 Q9Z1F9 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9UBT2 (/IMP)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9UBT2 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9Z1F9 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
9 Q28GH3 (/ISS) Q54L40 (/ISS) Q642Q1 (/ISS) Q7KUA4 (/ISS) Q7SXG4 (/ISS) Q7ZY60 (/ISS) Q9SJT1 (/ISS) Q9VSD9 (/ISS) Q9Z1F9 (/ISS)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
5 P52488 (/IMP) Q5BAI0 (/IMP) Q7KUA4 (/IMP) Q9UBT2 (/IMP) Q9VSD9 (/IMP)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
4 P52488 (/IDA) Q9NAN1 (/IDA) Q9SJT1 (/IDA) Q9UBT2 (/IDA)
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
2 Q7KUA4 (/IMP) Q9VSD9 (/IMP)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
2 O42939 (/ISO) Q9Z1F9 (/ISO)
Positive regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034126
Any process that activates or increases the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway.
2 Q7KUA4 (/IMP) Q9VSD9 (/IMP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 Q7KUA4 (/IDA) Q9VSD9 (/IDA)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q9NAN1 (/IGI)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q9NAN1 (/IGI)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
1 Q9SJT1 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q9NAN1 (/IGI)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
1 Q9UBT2 (/TAS)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 O42939 (/IDA) P52488 (/IDA) Q7KUA4 (/IDA) Q9SJT1 (/IDA) Q9VSD9 (/IDA)
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
4 Q54L40 (/ISS) Q7KUA4 (/ISS) Q9NAN1 (/ISS) Q9VSD9 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q7KUA4 (/IDA) Q9VSD9 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O42939 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9UBT2 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9Z1F9 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9UBT2 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9SJT1 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 Q9SJT1 (/IDA)
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
1 Q9UBT2 (/IDA)
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
1 P52488 (/IPI)
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
1 Q9Z1F9 (/ISO)
SUMO activating enzyme complex GO:0031510
A conserved heterodimeric complex with SUMO activating enzyme activity.
1 O42939 (/TAS)
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